Evidence map›Paper›PMID 42051224›Full record

ArticleMolecular plant pathology2026

The Dual Role of Methyl Caffeate: Growth Inhibition of Pseudomonas syringae and Induction of Resistance to Bacterial Speck Disease in Tomato.

Yarui Yang, Jikai Yu, Jinxi Yang, Yulin Wang, Wenrui Hou, Dongfang Zhang, Jianquan Wang, Wenfeng Nie, Yan Zhang, Xiaoyun Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular plant pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yarui YangCollege of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an, Shandong Province, China.ORCID 0009-0002-3695-241X
Jikai YuCollege of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an, Shandong Province, China.
Jinxi YangCollege of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an, Shandong Province, China.
Yulin WangCollege of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an, Shandong Province, China.
Wenrui HouCollege of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an, Shandong Province, China.
Dongfang ZhangCollege of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an, Shandong Province, China.
Jianquan WangCollege of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an, Shandong Province, China.
Wenfeng NieCollege of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an, Shandong Province, China.
Yan ZhangCollege of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an, Shandong Province, China.
Xiaoyun WangCollege of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an, Shandong Province, China.
Xiuming LiCollege of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an, Shandong Province, China.
Qinghua ShiCollege of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an, Shandong Province, China.

Funding

Government of Shandong Province 2022TZXD0025Government of Shandong Province 2024LZGCQY006Government of Shandong Province SDARS-05
6 · The paper itself

Abstract

Bacterial speck of tomato, caused by Pseudomonas syringae pv. tomato (Pst), is a globally significant disease leading to substantial yield losses. This study demonstrated that methyl caffeate (MC), a plant-derived phenolic acid, exhibited dual functionality against Pst strain DC3000 through direct antibacterial action and indirect host resistance priming. In vitro assays revealed MC's potent inhibitory activity against bacterial growth, characterised by disruption of membrane integrity, leading to intracellular content leakage and reactive oxygen species (ROS) accumulation. Transcriptomic analysis identified 434 upregulated and 326 downregulated genes, with differentially expressed genes primarily enriched in pathways related to flagellar assembly, motility, quorum sensing, chemotaxis and the type III secretion system (T3SS), thereby impairing bacterial motility and virulence. Concurrently, MC enhances plant defence responses by inducing the transcriptional expression of defence hormone signalling pathway-related genes and increasing the activities of defence enzymes such as phenylalanine ammonia-lyase (PAL) and polyphenol oxidase (PPO). This modulation helps maintain ROS homeostasis and alleviates oxidative damage caused by Pst infection, thereby attenuating disease progression. These findings established MC as a multifunctional agent combining direct bactericidal effects with plant immunity induction, providing a sustainable strategy for bacterial speck management.

Indexed as

Caffeic AcidsDisease ResistancePlant DiseasesPseudomonas syringaeSolanum lycopersicumGene Expression Regulation, PlantReactive Oxygen SpeciesCaffeic AcidsReactive Oxygen Speciesantibacterial activitymethyl caffeatePst DC3000tomato

Identifiers

PMID42051224
PMCPMC13126087

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.