Evidence map›Paper›PMID 42051170›Full record

ArticleJournal of medicinal chemistry2026

Pyridinophane Ligands: An Attractive Chelator Platform for Mn-Based Imaging Agents.

Tarek El Sayed, Karna Terpstra, Jennifer Whetter, Kerui Xu, Lingyang Zhu, Sagnik Chakrabarti, Axia Marlin, Andrew Wessel, Shreyan Majumdar, Bradley P Sutton and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Emerging Theranostic Radiometals (Pharmaceuticals (Basel, Switzerland) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tarek El SayedDepartment of Chemistry, Beckman Institute for Advanced Science and Technology, The Neuroscience Program, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, United States.ORCID 0000-0002-8024-6101
Karna TerpstraDepartment of Chemistry, Beckman Institute for Advanced Science and Technology, The Neuroscience Program, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, United States.
Jennifer WhetterDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States.
Kerui XuDepartment of Chemistry, Beckman Institute for Advanced Science and Technology, The Neuroscience Program, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, United States.
Lingyang ZhuDepartment of Chemistry, Beckman Institute for Advanced Science and Technology, The Neuroscience Program, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, United States.ORCID 0000-0002-6657-271X
Sagnik ChakrabartiDepartment of Chemistry, Beckman Institute for Advanced Science and Technology, The Neuroscience Program, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, United States.
Axia MarlinDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States.
Andrew WesselDepartment of Chemistry, Washington University, St. Louis, Missouri 63130, United States.
Shreyan MajumdarBeckman Institute for Advanced Science and Technology, Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana Illinois 61801, United States.
Bradley P SuttonBeckman Institute for Advanced Science and Technology, Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana Illinois 61801, United States.
Eszter BorosDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States.ORCID 0000-0002-4186-6586
Liviu M MiricaDepartment of Chemistry, Beckman Institute for Advanced Science and Technology, The Neuroscience Program, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, United States.ORCID 0000-0003-0584-9508

Funding

TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Hersh Chandarana · 2014 to 2026
$19.3M
Blood-Brain Barrier Permeable Multimodal Imaging Agents for Neurodegenerative DiseasesRF1AG083937 · NIA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI MIRICA, LIVIU M. · 2023 to 2023
$1.8M
NIA NIH HHS RF1 AG083937NIBIB NIH HHS P41 EB017183
6 · The paper itself

Abstract

Manganese-based magnetic resonance imaging (MRI) contrast agents were developed using chelators derived from the 2,11-diaza[3.3](2,6)pyridinophane macrocycle to enhance Mn

Indexed as

Aza CompoundsChelating AgentsContrast MediaHepatobiliary EliminationKidneyPyridinesRenal EliminationUrinary BladderAnimalsLigandsMagnetic Resonance ImagingMiceMice, Inbred BALB CPositron-Emission TomographyAza CompoundsChelating AgentsContrast MediaLigandsPyridines

Identifiers

PMID42051170
PMCPMC13193324

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.