ArticleAnnals of medicine2026
ICSI shows no advantage over conventional IVF in patients with unexpected low oocyte yield.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundA yield of fewer than five oocytes is associated with a sharp drop in success rates, making each oocyte extremely valuable and demanding highly efficient utilization. Therefore, we aimed to explore the optimal fertilization method for these patients.
methodsThis retrospective cohort single-center study included 424 C-IVF cycles and 90 ICSI cycles from 2016 to 2023. All patients were in their first ART cycle, with 3 or 4 oocytes retrieved. The study subjects were primarily divided into two groups: the IVF-LN (C-IVF with a 50% lower-than-expected oocyte yield) group and the ICSI-LN (ICSI with a 50% lower-than-expected oocyte yield) group.
resultsWe observed no significant differences in the day 3 available embryo (87.0 versus 84.8%;
conclusionFor patients with <5 Oocytes and a predicted yield of ≤50%, ICSI did not demonstrate a significant advantage over C-IVF.
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