Evidence map›Paper›PMID 42051021›Full record

Trial reportActa dermato-venereologica2026

Autologous Patch Healing vs Secondary Intent Healing after Mohs Micrographic Surgery: A Randomized Controlled Trial.

Marie K Hjorth, Ewa A Burian, Tonny Karlsmark, Mette Mogensen, Martin Glud, Anna Ahm Harager, Anthony Rossi, Katrine E Karmisholt

Abstract readRandomized Controlled TrialComparative Study
In one paragraph

Trial report in Acta dermato-venereologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marie K HjorthDepartment of Dermatology and Venereology Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospitals, Denmark. marie.kirstine.hjorth@regionh.dk.
Ewa A BurianDepartment of Dermatology and Venereology Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospitals, Denmark.
Tonny KarlsmarkDepartment of Dermatology and Venereology Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospitals, Denmark.
Mette MogensenDepartment of Dermatology and Venereology Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospitals, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark.
Martin GludDepartment of Dermatology and Venereology Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospitals, Denmark.
Anna Ahm HaragerDepartment of Dermatology and Venereology Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospitals, Denmark.
Anthony RossiDepartment of Dermatology, Memorial Sloan Kettering Cancer Center, New York, USA.
Katrine E KarmisholtDepartment of Dermatology and Venereology Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospitals, Denmark.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Secondary intent healing is a viable option for wound closure after facial tumour removal by Mohs micrographic surgery. Secondary intent healing involves prolonged healing time and carries risk of infection and complications related to scarring. Healing with an autologous patch made from the patient's own blood may be beneficial. This study on 22 patients evaluates the effect of applying an autologous patch to the wound after Mohs micrographic surgery. A randomized controlled assessor-blinded trial was carried out. Patients had Mohs micrographic surgery on day 0 and clinical evaluation on day 12, day 19, and after 6 months. Transepidermal water loss was measured on day 12 and day 19. Reflectance confocal microscopy was applied exploratively. At 6 months' follow-up the Patient and Observer Scar Assessment Scale was evaluated. Primary outcome was fully epithelialized wounds on day 19 and secondary outcome was 50% epithelialized wounds on day 12. One wound from each group was fully epithelialized and wound area reduction was higher in the patch group although not significant. Transepidermal water loss decreased to a larger extent, indicating that the patch creates a moist environment. Wound healing with an autologous patch is equivalent to secondary intent healing but may prompt benefits in certain wound healing factors. Patch healing appears safe with high patient satisfaction.

Indexed as

Facial NeoplasmsMohs SurgerySkin NeoplasmsWound HealingAgedAged, 80 and overFemaleHumansMaleMicroscopy, ConfocalMiddle AgedPatient SatisfactionRe-EpithelializationTime FactorsTreatment OutcomeWater Loss, Insensible

Identifiers

PMID42051021
PMCPMC13137085

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.