Evidence map›Paper›PMID 42051019›Full record

ArticleACS chemical neuroscience2026

Multi-Target Neuroprotective Compound Exhibits EAAT2-Modulating and Alzheimer's Pathology-Attenuating Effects in In Vitro and In Vivo Models.

Ahmet Hacımüftüoğlu, Nurullah Saraçoğlu, Sana Saffour, Nadeem Abad, Yunus Kesgun, Nadjiba Zegheb, Ersin Gundeger, Fatma Yeşilyurt, Merve Nur Ataş, Gizem Bati-Ayaz and 9 more

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ahmet HacımüftüoğluDepartment of Medical Pharmacology, Faculty of Medicine, Atatürk University, 25240 Erzurum, Turkey.
Nurullah SaraçoğluDepartment of Chemistry, Faculty of Sciences, Atatürk University, 25240 Erzurum, Turkey.ORCID 0000-0002-1504-7480
Sana SaffourTrustlife Laboratories Drug Research & Development Center, 34774 İstanbul, Turkey.ORCID 0000-0001-8124-9315
Nadeem AbadTrustlife Laboratories Drug Research & Development Center, 34774 İstanbul, Turkey.
Yunus KesgunTrustlife Laboratories Drug Research & Development Center, 34774 İstanbul, Turkey.
Nadjiba ZeghebTrustlife Laboratories Drug Research & Development Center, 34774 İstanbul, Turkey.
Ersin GundegerBiochemistry Department, Faculty of Pharmacy, Istanbul Health and Technology University, Sütlüce, Beyoğlu, 34275 İstanbul, Turkey.
Fatma YeşilyurtDepartment of Medical Pharmacology, Faculty of Medicine, Atatürk University, 25240 Erzurum, Turkey.
Merve Nur AtaşTrustlife Laboratories Drug Research & Development Center, 34774 İstanbul, Turkey.
Gizem Bati-AyazTrustlife Laboratories Drug Research & Development Center, 34774 İstanbul, Turkey.
Öznur AltunluDepartment of Medical Pharmacology, Faculty of Medicine, Atatürk University, 25240 Erzurum, Turkey.
Burak ÇınarDepartment of Medical Pharmacology, Faculty of Medicine, Atatürk University, 25240 Erzurum, Turkey.
Mehmet Ali YörükDepartment of Medical Pharmacology, Faculty of Medicine, Atatürk University, 25240 Erzurum, Turkey.
Ufuk OkkayDepartment of Medical Pharmacology, Faculty of Medicine, Atatürk University, 25240 Erzurum, Turkey.ORCID 0000-0002-2871-0712
Mustafa ÖzkaracaFaculty of Veterinary Medicine, Department of Pathology, Cumhuriyet University, 58140 Sivas, Turkey.
Orhan AteşDepartment of Eye Diseases, Faculty of Medicine, Atatürk University, 25240 Erzurum, Turkey.
Ali TaghizadehghalehjoughiDepartment of Medical Pharmacology, Faculty of Medicine, Bilecik Seyh Edebali University, 11230 Bilecik, Turkey.
Ferruh LafziDepartment of Chemistry, Faculty of Sciences, Atatürk University, 25240 Erzurum, Turkey.
Hasan TürkezDepartment of Medical Biology, Faculty of Medicine, Atatürk University, 25240 Erzurum, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a debilitating neurodegenerative disorder characterized by cognitive decline and memory loss. Current treatments offer limited efficacy, necessitating the development of innovative multitarget therapeutic strategies. Here, we present

Indexed as

Alzheimer DiseaseExcitatory Amino Acid Transporter 2Neuroprotective AgentsAnimalsAstrocytesCells, CulturedCell SurvivalDisease Models, AnimalDonepezilFemaleGlutamic AcidHippocampusNeuronsRatsRats, Sprague-DawleyDonepezilExcitatory Amino Acid Transporter 2Glutamic AcidNeuroprotective AgentsSlc1a2 protein, ratglutamate excitotoxicityneurodegenerationoxidative stressTau pathologyβ-Amyloid pathology

Identifiers

PMID42051019
PMCPMC13195668

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.