SynthesisThe Journal of international medical research2026
Effects of probiotic supplementation on glycemic control in children with type 1 diabetes: A systematic review and meta-analysis.
Synthesis in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
8 authors.
Funding
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Abstract
BackgroundThis study aimed to evaluate the effects of probiotic supplementation on glycemic control in children with type 1 diabetes, as measured using glycated hemoglobin level, fasting blood glucose level, and insulin requirements.MethodsA systematic search was conducted across four databases (PubMed, Web of Science, Embase, and Scopus) to identify eligible randomized controlled trials. The Cochrane Risk of Bias tool was used to assess methodological quality. Meta‑analyses were performed using random‑effects models, with subgroup analysis conducted by probiotic strain. The study was registered with the Research Registry (reviewregistry2089).ResultsSix randomized controlled trials (483 children) were included. Probiotic supplementation significantly reduced glycated hemoglobin levels (weighted mean difference: -0.54%; 95% confidence interval: -0.90% to -0.18%;
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