ArticleCancer biology & therapy2026
Parthenolide inhibits the progression of intrahepatic cholangiocarcinoma by promoting ferroptosis through inhibiting UBD.
Article in Cancer biology & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study aimed to investigate the antitumor activity and molecular mechanism of Parthenolide (Par) against intrahepatic cholangiocarcinoma (ICC), a highly malignant liver tumor with poor prognosis, to explore potential new treatment strategies.
methodsPar was identified through screening an FDA compound library.
resultsPar significantly inhibited ICC cell proliferation, colony formation, invasion, and migration, induced G2/M phase arrest, and promoted apoptosis
conclusionThis study demonstrates for the first time that Par exerts anti-ICC effects related to inhibition of UBD, thereby activating the ferroptosis pathway. These findings provide a novel potential strategy and therapeutic target for ICC treatment.
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