ArticleCancer medicine2026
Challenges in Diagnosing and Treating Percutaneous Nephrostomy-Related Urinary Tract Infection in Cancer Patients: A Retrospective Cohort Study.
Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
objectiveWe aimed to evaluate medical decisions regarding urinary tract infection (UTI), describe associated microorganisms, and assess potential risk factors for percutaneous nephrostomy-related UTI (UTI-PN).
methodsOncological patients who underwent percutaneous nephrostomy (PN) were included. We assessed percutaneous nephrostomy procedure-related UTI (UTI-PNp) when the UTI occurred until 7 days after the PN and percutaneous nephrostomy catheter-related UTI (UTI-PNc) when the UTI occurred > 7 days after PN.
resultsA total of 734 PN procedures were performed (45.4% first catheter placement, 54.6% catheter replacement). Fever was the primary clinical indicator guiding treatment decisions for both UTI-PNp (43.3%; 26/60) and UTI-PNc (44.6%; 99/222). Leukocyturia, either alone or combined with turbid urine, foul-smelling urine, or leukocytosis, influenced treatment decisions in 5.0% (3/60) of UTI-PNp cases and 17.1% (38/222) of UTI-PNc cases. No risk factors were identified for UTI-PNp; however, the time between urinary tract obstruction and the placement of the PN for decompression increased the odds of developing UTI-PNc. Among urine cultures, multidrug-resistant bacteria accounted for 57.7% (41/71) in cases with three to six antibiotic use episodes, compared to 42.3% (30/269) of cases of multidrug-sensitive bacteria (p < 0.001).
conclusionBeyond the paramount importance of achieving an accurate infection diagnosis to mitigate the prevalence of multidrug-resistant bacteria, our results highlight differences between UTI-PNc and UTI-PNp, including risk factors, underscoring the need for distinct approaches to UTI-PN.
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