ArticleClinical and translational science2026
Revealing Non-Motor Symptom Profiles of Orthostatic Hypotension Subtypes in Parkinson's Disease: Insights From a Multidimensional Case-Control Study.
Article in Clinical and translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Orthostatic hypotension (OH) represents a cardinal non-motor manifestation in Parkinson's disease (PD), yet the clinical relevance of its subtypes remains unclear. This study aimed to characterize the clinical and blood pressure (BP) profiles of PD-OH and its subtypes. We enrolled 186 PD patients, including 59 with OH, and collected clinical, postural BP, autonomic, cognitive, emotional, sleep, and REM sleep behavior disorder (RBD) data. Analyses used t-tests, nonparametric tests, and chi-square tests as appropriate. Compared to PD-nOH, PD-OH patients had later onset, higher RBD prevalence, poorer visuospatial function, and better subjective sleep quality. They exhibited lower systolic/diastolic BP (SBP/DBP) and larger orthostatic drops across postures. Within PD-OH, diastolic OH with greater cognitive impairment and specific sleep alterations, while symptomatic with worse motor and autonomic function. RBD was linked to greater autonomic dysfunction; depressive symptoms specifically distinguished PD-OH-RBD, whereas cognitive differences distinguished PD-RBD. Advanced PD-OH showed lower SBP/DBP, especially when seated and immediately after standing. In conclusion, D-OH and symptomatic OH are associated with more severe non-motor symptoms, with cognitive and depressive profiles helping distinguish the interaction of PD, OH, and RBD.
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