ArticleVeterinary research2026
Integrative comparative genomics and transcriptomics reveal key roles of SAG17 and SAG23 in early-stage virulence divergence of Eimeria tenella.
Article in Veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Eimeria tenella is one of the major pathogens threatening the poultry industry. However, the molecular mechanisms underlying the divergence of virulence among geographic strains remain poorly understood. In this study, clinical phenotypes, histopathology, cytokine assays, whole-genome resequencing, and transcriptome analyses were integrated to systematically compare the Beijing and Guizhou strains. The results showed that infection with the Guizhou strain caused more severe clinical symptoms and intestinal lesions in chickens, accompanied by stronger interleukin (IL)-17 and tumor necrosis factor (TNF)-α responses. Genomic variation analysis revealed abundant nonsynonymous and promoter mutations in the surface antigen (SAG) membrane protein family of the Guizhou strain, and transcriptomic data further confirmed high sporozoite-stage expression of SAG5, SAG13, SAG17, and SAG23, which strongly correlated with virulence phenotypes. Functional validation demonstrated that the recombinant SAG17 and SAG23 proteins significantly inhibited invasion by the E. tenella sporozoites and enhanced levels of the host's interferon (IFN)-γ and immunoglobulin G (IgG), with SAG17 showed stronger immunostimulatory effects than SAG23. Collectively, this study identified SAG17 and SAG23 as key molecules driving virulence divergence of E. tenella geographic strains, providing molecular evidence for the mechanisms of parasite virulence and highlighting important targets for the development of novel vaccines and anticoccidial drugs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.