ReviewChinese medicine2026
Targeting tumor-associated macrophages through phytochemicals: a promising strategy for cold tumor therapy.
Review in Chinese medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Immunotherapy serves as the fourth modality for cancer treatment, following surgery, radiotherapy, and chemotherapy. However, its efficacy remains inconsistent due to the heterogeneity of the tumor microenvironment (TME). Tumors characterized by an immunosuppressive TME that are unresponsive to immunotherapy are termed "cold tumors." Thus, strategies to reverse this immunosuppressive environment are promising for treating cold tumors. Tumor-associated macrophages (TAMs) play a significant role in this process, making TAM-targeting therapies potentially valuable. Natural products (NPs), which are bioactive compounds from traditional herbs, exhibit broad anticancer effects and modulate TAM polarization, positioning them as a promising source for anticancer agents. This article explores the relationship between TAMs and the TME, emphasizing the mechanisms by which natural products, such as terpenoids and quinones, influence TAM polarization to inhibit tumor progression. By analyzing TAM roles in the TME and summarizing existing natural products targeting TAM polarization, this study offers insights for developing novel TAM-targeting drugs, and aids in the conversion of cold tumors to hot tumors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.