ReviewVirology journal2026
Therapeutic modulation of HIV-1 using miRNAs and lncRNAs: from bench to bedside.
Review in Virology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Epigenetic regulation of HIV-1 transcription: insights into latency mechanisms and therapeutic strategies.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long non-coding RNAs, often referred to as lncRNAs, consist of RNA molecules that contain more than 200 nt and can be translated into small proteins under various circumstances. Extensive research has consistently demonstrated that long non-coding RNAs (lncRNAs) and miRNAs play a crucial role in various biological processes and disease mechanisms, including those associated with viral infections. Although numerous mechanisms are involved in miRNA and lncRNA-mediated gene regulation, such as transcriptional and translational regulation, protein modification, and the formation of RNA-protein complexes. This manuscript demonstrates the new therapeutic roles of long ncRNA (lncRNA) and microRNA (miRNA) in the treatment of HIV-1 infection. It shows that these non-coding RNAs have decisive roles in controlling the viral replication, latency, and host-virus interactions in the epigenetic, transcriptional and post-transcriptional processes. Select lncRNAs like MALAT1, NEAT1, NRON, and GAS5 are demonstrated to increase or block HIV transcription and persistence, whereas miRNAs like miRNA-155, miRNA-146a and miRNA-191- 5p regulate immune reactions and viral replication by acting on both viral RNA and host dynamics. The article also highlights that certain disadvantage of lncRNA such as delivery efficiency, stability of RNA therapeutics, potential off-target effects, and the difficulty of targeting HIV reservoirs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.