Evidence map›Paper›PMID 42050678›Full record

Observational studyBMC research notes2026

Calcium and zinc status and risk of preeclampsia in pregnant women with varying seafood intake in Ambon City: a case-control study.

Merlin Margreth Maelissa, Anita Deborah Anwar, Johanes Cornelius Mose, Sofie Rifayani Krisnadi, Marliyati Sanaky, Arlen Resnawaldi, Udin Sabarudin, Akhmad Yogi Pramatirta, Adhi Pribadi

Abstract readObservational Study
In one paragraph

Observational study in BMC research notes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Merlin Margreth MaelissaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Pattimura University, Ambon, 97233, Indonesia. maelissamerlin@gmail.com.
Anita Deborah AnwarMaternal Fetal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran; Dr. Hasan Sadikin General Hospital, Bandung, 40161, Indonesia.
Johanes Cornelius MoseMaternal Fetal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran; Dr. Hasan Sadikin General Hospital, Bandung, 40161, Indonesia.
Sofie Rifayani KrisnadiMaternal Fetal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran; Dr. Hasan Sadikin General Hospital, Bandung, 40161, Indonesia.
Marliyati SanakyDepartment of Obstetrics and Gynecology, Faculty of Medicine, Pattimura University, Ambon, 97233, Indonesia.
Arlen ResnawaldiDepartment of Obstetrics and Gynecology, Faculty of Medicine, Pattimura University, Ambon, 97233, Indonesia.
Udin SabarudinMaternal Fetal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran; Dr. Hasan Sadikin General Hospital, Bandung, 40161, Indonesia.
Akhmad Yogi PramatirtaMaternal Fetal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran; Dr. Hasan Sadikin General Hospital, Bandung, 40161, Indonesia.
Adhi PribadiMaternal Fetal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran; Dr. Hasan Sadikin General Hospital, Bandung, 40161, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreeclampsia is a significant cause of maternal morbidity and mortality, often influenced by maternal nutrition. Calcium and zinc are essential micronutrients implicated in the prevention of preeclampsia. This study examines their levels in pregnant women consuming seafood in Ambon City as a local data that could support global data.

methodsThis analytical observational study used a case-control design. Calcium and zinc levels were assessed in 120 pregnant women (60 with preeclampsia, 60 without preeclampsia) attending medical facilities in Ambon from June to October 2024. Statistical analyses, including Chi-square tests, were performed. A P-value < 0.05 was considered statistically significant.

resultsPregnant women with preeclampsia in Ambon City had lower calcium levels than those without preeclampsia, especially among those consuming less than four pieces of sea fish per day (≈ 120 g each) (borderline (OR = 3.143, p = 0.053)). Zinc levels showed no significant difference. Women with preeclampsia had a 10.286-fold increased likelihood of low calcium levels.

conclusionIn Ambon City, pregnant women with preeclampsia have lower calcium levels than those without, while zinc levels remain similar between both groups. Higher fish consumption (at least four medium-sized pieces per day) is linked to higher calcium levels in both preeclamptic and non-preeclamptic women, but zinc levels are unaffected by fish intake.

Indexed as

CalciumPre-EclampsiaSeafoodZincAdultAnimalsCase-Control StudiesFemaleHumansPregnancyRisk FactorsCalciumZincMarine diet in pregnancyMicronutrient deficiencyPreeclampsia

Identifiers

PMID42050678
PMCPMC13126712

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.