ArticleJournal of nanobiotechnology2026
Tower-shaped super-adhesive microneedles loaded with vitamin A-containing Bletilla striata vesicles: temporally regulated Inflammation resolution and ECM remodeling for scarless wound healing.
Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Pathological scars, resulting from abnormal collagen metabolism during wound healing, pose clinical challenges due to the high recurrence rates of conventional treatments. Therefore, early-stage modulation of the wound healing process is emerging as a pivotal strategy for preventing and treating pathological scars, necessitating precise coordination of vascular regeneration, inflammation regulation, cell migration, and collagen remodeling. Here, we developed a 3D-printed tower-shaped microneedle system (BSEVs@VA-HP MNs) loaded with vitamin A (VA)-containing Bletilla striata vesicles (BSEVs@VA) for functionally staged effects supported by release kinetics in scarless wound healing. The BSEVs@VA-HP MNs demonstrate exceptional mechanical strength, making them highly effective in penetrating the skin, adhering to tissues, and enzyme-responsive degradation. In rat wound models and rabbit ear scar models, the BSEVs@VA-HP MNs gradually dissolve and release BSEVs, which passively target and are internalized by cells. These BSEVs reprogram macrophages toward an M2 phenotype, mediating anti-inflammatory effects while simultaneously promoting angiogenesis and cell migration. Upon cellular internalization, lysosomes degrade BSEVs, liberating VA, which regulates the type I/III collagen balance during tissue remodeling, thereby suppressing myofibroblast activation and facilitating scarless wound healing. This study integrates natural plant-derived vesicles with 3D-printed bioinspired microneedle technology to establish a synergistic, stage-coordinated therapeutic strategy for scarless wound healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.