Evidence map›Paper›PMID 42050277›Full record

ArticleHeart and vessels2026

Left atrium dysfunction and dyssynchrony in pediatric patients with Wolff-Parkinson-White syndrome assessed using speckle-tracking echocardiography.

Hirohisa Kago, Hideo Fukunaga, Azusa Akiya, Satoshi Akimoto, Mayumi Ifuku, Takeshi Iso, Yu Hosono, Sachie Shigemitsu, Ken Takahashi, Toshiaki Shimizu

Abstract read
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In one paragraph

Article in Heart and vessels, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Hirohisa KagoDepartment of Pediatrics and Adolescent Medicine, Graduate School of Medicine, Juntendo University, 3-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.ORCID http://orcid.org/0009-0005-9116-539X
Hideo FukunagaDepartment of Pediatrics, Faculty of Medicine, Juntendo University, 3-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. fukunaga@juntendo.ac.jp.
Azusa AkiyaDepartment of Pediatrics, Faculty of Medicine, Juntendo University, 3-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Satoshi AkimotoDepartment of Pediatrics, Faculty of Medicine, Juntendo University, 3-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Mayumi IfukuDepartment of Pediatrics, Faculty of Medicine, Juntendo University, 3-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Takeshi IsoDepartment of Pediatrics, Faculty of Medicine, Juntendo University, 3-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Yu HosonoDepartment of Pediatrics, Faculty of Medicine, Juntendo University, 3-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Sachie ShigemitsuDepartment of Pediatrics, Faculty of Medicine, Juntendo University, 3-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Ken TakahashiDepartment of Pediatrics, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu city, 279-0021, Chiba, Japan.
Toshiaki ShimizuDepartment of Pediatrics and Adolescent Medicine, Graduate School of Medicine, Juntendo University, 3-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients with manifest Wolff–Parkinson–White syndrome (WPWS), the ventricles are electrically and mechanically pre-excited via an accessory pathway (AP; left-sided AP: type A, right-sided AP: type B). Left ventricular (LV) dyssynchrony contributes to LV dysfunction. Although left atrial (LA) function is recognized as a sensitive indicator of clinical outcomes in various diseases, there have been no reports on LA function in pediatric patients with WPWS. We measured LA and LV strain and dyssynchrony indices in patients with WPWS (W-group: 36 participants) and normal controls (N-group: 41 participants) categorized by age (Group 1 ≦ 11 years, Group 2 ≧ 12 years). LA reservoir strain (LASr) in the W group was significantly lower than those in the N group in both age groups. LASr showed weak to moderate correlation with LV dyssynchrony index in Group 1 and with LV strain in Group 2. No significant differences were observed in LASr between types A and B within each age group. In Group 1, the LV longitudinal strain (LVLS) of type B was significantly lower than that in the N group. In Group 2, LVLS in both types was lower than that in the N group. The location of AP did not significantly impact LA dysfunction, which primarily correlated with LV dyssynchrony in younger patients and LV dysfunction in older patients. LA dyssynchrony was observed in both age groups. LA phasic strain may serve as an early indicator of cardiac dysfunction.

Indexed as

Cardiac dysfunctionLeft atrium strainLeft ventricular strainWolff–Parkinson–White (WPW) syndrome

Identifiers

PMID42050277

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.