ReviewAnnals of surgical oncology2026
Mapping the Evidence for Surgical Care of Gastro-Entero-Pancreatic Neuroendocrine Tumors (GEP-NETs): A Scoping Review.
Review in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Surgeons, Time to Step Up! Building Quality Surgical Evidence in Gastroenteropancreatic Neuroendocrine Tumors.Annals of surgical oncology · 2026Article
- Strengthening the Surgical Evidence Base in Gastro-Entero-Pancreatic Neuroendocrine Tumors.Annals of surgical oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurgical management remains the cornerstone in the management of gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs), yet surgical indications and procedures are often inconsistent. To inform the development of a research agenda to strengthen the evidence in NETs surgical care, we conducted a scoping review to map the existing literature on surgery for gastro-entero-pancreatic (GEP) NETs. MATERIALS AND
methodsThe scoping review was conducted following the expanded framework of Arksey and O'Malley. A literature search was run on MEDLINE, Embase, and Scopus in October 2024 for studies published since 2000 reporting on any surgical intervention, performed under general or loco-regional anesthesia on adults with GEP-NETs at any stage.
resultsAmong the 10,000 studies screened, 260 were included. Publications included were mostly reviews covering a broad range of topics. Of the 120 original investigations, 96.7% were retrospective cohort studies and 43% were single center. There were only four prospective cohort studies. Of all publications included, the most common topics were observation of small pancreatic NETs, treatment of liver metastases, safety of minimally invasive surgery, and prognostication. Of original investigations, the majority compared surgical approaches, followed by examination of lymph node harvest and defining size cutoff for observation of pancreatic NETs.
conclusionsThis scoping review highlights limitations and gaps in the evidence supporting surgical care for GEP-NETs. Very few original investigations report prospective or multi-institutional data, and examination of pancreatic NETs dominate the literature. Future research should prioritize prospective, multi-institutional studies, stage- and primary-site-specific analyses, and interventional trials evaluating surgery relative to other therapies.
Indexed as
Identifiers
42050252What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.