Evidence map›Paper›PMID 42050202›Full record

ArticleJournal of anesthesia2026

Transmembrane protein 45b in peripheral sensory neurons selectively mediates IL-31-dependent chemical itch.

Tomoyuki Maruyama, Akari Yoshida, Shogo Sunami, Akihiro Ura, Hiromichi Kurosaki, Tomoyuki Kawamata

Abstract read
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In one paragraph

Article in Journal of anesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Tomoyuki MaruyamaDepartment of Anesthesiology, Wakayama Medical University School of Medicine, 811-1 Kimiidera, Wakayama, 640-0012, Japan.
Akari YoshidaDepartment of Anesthesiology, Wakayama Medical University School of Medicine, 811-1 Kimiidera, Wakayama, 640-0012, Japan.
Shogo SunamiDepartment of Anesthesiology, Wakayama Medical University School of Medicine, 811-1 Kimiidera, Wakayama, 640-0012, Japan.
Akihiro UraDepartment of Anesthesiology, Wakayama Medical University School of Medicine, 811-1 Kimiidera, Wakayama, 640-0012, Japan.
Hiromichi KurosakiDepartment of Anesthesiology, Wakayama Medical University School of Medicine, 811-1 Kimiidera, Wakayama, 640-0012, Japan.
Tomoyuki KawamataDepartment of Anesthesiology, Wakayama Medical University School of Medicine, 811-1 Kimiidera, Wakayama, 640-0012, Japan. kawamata@wakayama-med.ac.jp.ORCID http://orcid.org/0000-0003-1535-6715

Funding

Grants-in-Aid for Scientific Research from the Japan Society for Promotion of Science JP21K08976Grants-in-Aid for Scientific Research from the Japan Society for Promotion of Science JP23H24428
6 · The paper itself

Abstract

purposeWe previously identified transmembrane protein 45b (Tmem45b) as a pain-related molecule essential for mechanical pain hypersensitivity but not for thermal pain hypersensitivity. A subset of Tmem45b is expressed in TRPV1-positive primary afferents, which are specialized in transmitting thermal pain and specific types of itch. Here, we examined the involvement of Tmem45b in itch perception.

methodsBehavioral experiments using Tmem45b knockout mice and wild-type mice were conducted to assess the role of Tmem45b in acute and chronic itch mediated by TRPV1-positive primary afferents. In addition, histochemical analyses were performed to identify Tmem45b-positive neurons in itch transmission.

resultsAcute itch induced by interleukin (IL)-31 and compound 48/80 was significantly attenuated in Tmem45b knockout (KO) mice compared with wild-type (WT) mice, whereas acute itch induced by histamine, the protease-activated receptor-2 activating peptide SLIGRL-NH

conclusionThese findings demonstrate that Tmem45b is selectively involved in IL-31-induced chemical itch and suggest that Tmem45b could serve as a novel modulator for IL-31-induced itch.

Indexed as

Dorsal root ganglionIn situ hybridizationItchScratching

Identifiers

PMID42050202

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.