ArticleArchives of toxicology2026
Assessment of cytotoxicity and genomic instability induced by coal-derived nanoparticles in V79 and HaCaT Cells.
Article in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coal is a major global energy resource, but its extraction raises significant environmental and health concerns. Mining activities release large amounts of particulate matter, including nanoparticles (NPs), into the environment. These NPs are hazardous due to their content of polycyclic aromatic hydrocarbons (PAHs), metals, oxides, and other compounds capable of disrupting cellular and molecular processes. This study evaluated the cytotoxic and genotoxic effects of coal-derived NPs on V79 and HaCaT cell lines, focusing on their impact on DNA stability and the mechanisms responsible for cellular damage. NPs were isolated using an acid-based separation method and applied to cells at concentrations of 50, 150, and 300 μg/mL. Atomic force microscopy (AFM) provided topographical characterization, while dynamic light scattering (DLS) confirmed their tendency to agglomerate. Scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy (SEM-EDS) confirmed NP morphology and elemental composition, including carbon, oxygen, iron, calcium, silicon, aluminum, and copper. Cytotoxicity was assessed using resazurin and sulforhodamine B assays, and genotoxicity was evaluated using the comet assay, micronucleus test, and γH2AX immunostaining. Results showed a clear dose-dependent effect, with coal NPs inducing genomic instability and increased cell mortality, mainly through apoptosis. These findings highlight the importance of characterizing coal-derived NPs to better assess their environmental and health risks, particularly regarding respiratory diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.