Evidence map›Paper›PMID 42050180›Full record

ArticleNature medicine2026

A reasonably likely surrogate endpoint for metabolic dysfunction-associated steatohepatitis.

Arun J Sanyal, Michelle T Long, Nancy Obuchowski, Roberto A Calle, Raj Vuppalanchi, Brent Neuschwander-Tetri, Rohit Loomba, Katherine Yates, Patricia Grebenstein, Melissa A Jones and 2 more

Abstract readLetter
PubMed Publisher
In one paragraph

Article in Nature medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Arun J SanyalStravitz-Sanyal Institute for Liver Disease and Metabolic Health, Division of Gastroenterology, Hepatology and Nutrition, VCU School of Medicine, Richmond, VA, USA. arun.sanyal@vcuhealth.org.ORCID http://orcid.org/0000-0001-8682-5748
Michelle T LongNovo Nordisk, Bagsvaerd, Denmark.ORCID http://orcid.org/0000-0001-6131-3981
Nancy ObuchowskiQuantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
Roberto A CalleRegeneron Pharmaceutical, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0001-6577-5657
Raj VuppalanchiDivision of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0003-0637-1577
Brent Neuschwander-TetriDivision of Gastroenterology and Hepatology, Saint Louis University School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0002-8520-7398
Rohit LoombaMASLD Research Center, Division of Gastroenterology and Hepatology, University of California, San Diego, San Diego, CA, USA.
Katherine YatesBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Patricia GrebensteinFoundation for the National Institutes of Health, North Bethesda, MD, USA.
Melissa A JonesFoundation for the National Institutes of Health, North Bethesda, MD, USA.
Tania N KamphausFoundation for the National Institutes of Health, North Bethesda, MD, USA.
Surrogate Endpoints Workstream of the FNIH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID42050180

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.