Evidence map›Paper›PMID 42050172›Full record

ArticleNature structural & molecular biology2026

TMPRSS2-mediated coronavirus spike activation and inhibition.

Matthew McCallum, James Brett Case, Jack T Brown, Young-Jun Park, Jimin Lee, Emmajay Sutherland, Anupriya Aggarwal, Cecily Gibson, Florian A Lempp, Cameron Stewart and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature structural & molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Matthew McCallum *Department of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8398-8330
James Brett Case *Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-7331-5511
Jack T Brown *Department of Biochemistry, University of Washington, Seattle, WA, USA.
Young-Jun Park *Department of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2901-6949
Jimin LeeDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Emmajay SutherlandDepartment of Chemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-5150-4346
Anupriya AggarwalThe Kirby Institute, The University of New South Wales, Sydney, New South Wales, Australia.
Cecily GibsonDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Florian A LemppVir Biotechnology, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6103-8078
Cameron StewartDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-2786-6256
M Alejandra TortoriciDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-2260-2577
Shilpa SanapalaDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Jun Siong LowInstitute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland.
Daniel AsarnowDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-7870-5308
Dana BohanVir Biotechnology, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-9239-3053
Exequiel DellotaVir Biotechnology, San Francisco, CA, USA.
Benjamin MerzDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Bhavna ChawlaBioqual, Rockville, MD, USA.
Swagata KarBioqual, Rockville, MD, USA.
Antonio LanzavecchiaVir Biotechnology, Bellinzona, Switzerland.ORCID http://orcid.org/0000-0002-3041-7240
Federica SallustoInstitute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland.
Nicholas M RileyDepartment of Chemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-1536-2966
Stuart TurvilleThe Kirby Institute, The University of New South Wales, Sydney, New South Wales, Australia.
Lisa PurcellVir Biotechnology, San Francisco, CA, USA.
Michael S DiamondDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA. mdiamond@wustl.edu.ORCID http://orcid.org/0000-0002-8791-3165
David VeeslerDepartment of Biochemistry, University of Washington, Seattle, WA, USA. dveesler@uw.edu.ORCID http://orcid.org/0000-0002-6019-8675

Funding

Structure-based design of broadly protective coronavirus vaccinesP01AI167966 · NIAID · UNIVERSITY OF WASHINGTON · PI Neil King · 2022 to 2026
$15.3M
Unraveling the bat humoral immune response against zoonotic viruses to guide the design of next-generation therapeuticsDP1AI158186 · NIAID · UNIVERSITY OF WASHINGTON · PI VEESLER, DAVID · 2020 to 2024
$5.4M
NIAID NIH HHS DP1 AI158186NIAID NIH HHS P01 AI167966
6 · The paper itself

Abstract

The protease TMPRSS2 facilitates coronavirus infections, yet its mechanism of viral glycoprotein recognition remains unclear. Here we show that, following ACE2 engagement of the SARS-CoV-2 spike (S) inducing the early fusion intermediate conformation (E-FIC), TMPRSS2 cleaves the R815 S

Indexed as

SARS-CoV-2Serine EndopeptidasesSpike Glycoprotein, CoronavirusAngiotensin-Converting Enzyme 2AnimalsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralCOVID-19HumansMiceVirus InternalizationAngiotensin-Converting Enzyme 2Antibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralSerine EndopeptidasesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2TMPRSS2 protein, human

Identifiers

PMID42050172
PMCPMC13186702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.