ArticleObesity surgery2026
Impact of Menopausal Status on Bone Metabolism and Body Composition After Metabolic-Bariatric Surgery: a Two-Year Prospective Study in Middle-Aged Women.
Article in Obesity surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionThe impact of menopausal status on metabolic and densitometric outcomes following metabolic-bariatric surgery (MBS) remains insufficiently characterized. This study aims to evaluate the association between menopausal status at the time of MBS and changes in bone mineral density (BMD) and body composition.
methodsProspective, single-center study including 162 patients undergoing MBS either Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG), between November/2019 and December/2022. Participants were divided into two groups based on menopause status at the time of surgery. Clinical and biochemical parameters were assessed preoperatively and at 6-, 12-, and 24-month post-surgery. Linear and logistic regression analyses were performed, adjusting for age, type of surgery, and baseline body mass index.
resultsPostmenopausal patients showed a higher prevalence of T2D, hypertension and osteopenia. Two years after MBS, postmenopausal patients revealed to have a steeper decrease in bone mineral content (-0.31 ± 0.13 g vs. -0.23 ± 0.14 g, adjusted p = 0.037), a higher loss of total femur (-0.18 ± 0.08 g/cm2 vs. -0.14 ± 0.08 g/cm2, p = 0.008) and whole-body bone mineral density (-0.14 ± 0.07 g/cm2 vs. -0.10 ± 0.13 g/cm2, p = 0.074). Postmenopausal patients presented a greater decrease in total body lean mass (-7.52 ± 3.06 kg vs. -7.27 ± 3.22 kg, p = 0.014) and arms lean mass (-1.00 ± 1.16 kg vs. -0.68 ± 0.90 kg, p = 0.020).
conclusionThis study demonstrates that, although weight loss is comparable between groups, postmenopausal women undergoing MBS experience a more significant loss of lean mass and bone mineral density. These findings underscore the need for tailored post-surgical strategies, including optimized nutritional support and vigilant bone health monitoring, to mitigate potential adverse effects in this population.
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