ReviewNature genetics2026
Insights into human adaptation from ancient DNA.
Review in Nature genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Genomic insights into natural selection in recent human history.Nature reviews. Genetics · 2026Review
- Bridging precision agriculture and human medicine through comparative genetics.Nature reviews. Genetics · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Ancient DNA (aDNA) has revolutionized our ability to study human evolution by enabling the direct observation of genetic changes through time. This has reshaped our understanding of human adaptation and its relevance for modern health and disease. In recent years, high-quality ancient genomes and large datasets have made it possible to track allele frequency dynamics and identify episodes of natural selection with unprecedented resolution. Here, we synthesize insights from recent studies that have systematically investigated how humans adapted to shifts in diet, mobility, pathogen exposure and environment. We summarize the approaches used to detect selection in aDNA, examine the role of major migration and admixture events and connect results across time periods and archaeological contexts. Finally, we outline future challenges and opportunities that need to be addressed for aDNA studies to provide new insights into human adaptation that could not be inferred from present-day genomes alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.