Evidence map›Paper›PMID 42049829›Full record

ArticleScientific reports2026

Neighborhood socioeconomic deprivation and physical activity associate with extracellular vesicle size and cargo in a community-based cohort of women.

Yvonne Baumer, Elizabeth M Aquino Peterson, Matthew R Bavuso, Noel Miller, Cristhian A Gutierrez-Huerta, Nithya P Vijayakumar, Sam J Neally, Kaveri Curlin, Valerie M Mitchell, Billy S Collins and 4 more

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yvonne Baumer *Social Determinants of Obesity and Cardiovascular Risk Laboratory, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Elizabeth M Aquino Peterson *Social Determinants of Obesity and Cardiovascular Risk Laboratory, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Matthew R BavusoDepartment of Biomedical and Translational Sciences, Eastern Virginia Medical School at Old Dominion University, Norfolk, VA, USA.
Noel MillerDepartment of Biomedical and Translational Sciences, Eastern Virginia Medical School at Old Dominion University, Norfolk, VA, USA.
Cristhian A Gutierrez-HuertaSocial Determinants of Obesity and Cardiovascular Risk Laboratory, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Nithya P VijayakumarSocial Determinants of Obesity and Cardiovascular Risk Laboratory, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Sam J NeallySocial Determinants of Obesity and Cardiovascular Risk Laboratory, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Kaveri CurlinSocial Determinants of Obesity and Cardiovascular Risk Laboratory, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Valerie M MitchellSocial Determinants of Obesity and Cardiovascular Risk Laboratory, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Billy S CollinsSocial Determinants of Obesity and Cardiovascular Risk Laboratory, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Neelam R RedekarIntegrative Data Sciences Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Subrata PaulIntegrative Data Sciences Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Anca D DobrianDepartment of Biomedical and Translational Sciences, Eastern Virginia Medical School at Old Dominion University, Norfolk, VA, USA.
Tiffany M Powell-WileySocial Determinants of Obesity and Cardiovascular Risk Laboratory, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA. tiffany.powell-wiley@nih.gov.

Funding

American Heart Association AIREA AwardIntramural Research Program NHLBINIMHD NIH HHS Coleman
6 · The paper itself

Abstract

African American (AA) women face disproportionate cardiovascular disease (CVD) risk due to adverse social determinants of health (SDoH), including lower socioeconomic status (SES). Physical activity (PA) and plasma extracellular vesicles (EVs) modulate CVD risk, but their relationships with SDoH remain unclear. This study examines associations between SDoH, PA, and plasma EVs in a Washington, DC-based cohort of at-risk AA women. Participants (N = 24, Age: 57 ± 12, BMI: 35 ± 6, ASCVD: 9 ± 5) joined the Step It Up Community-Engaged, Digital Health Physical Activity Intervention pilot study. EVs were isolated from fasting plasma samples. Multivariable regression, adjusted for BMI and ASCVD 10-year risk, showed that neighborhood socioeconomic deprivation (NSD) was associated with decreased EV size (β=-0.49, p = 0.01), while higher daily step count was associated with increased EV size (β = 0.48, p = 0.02). EV miRNA cargo, including miR-1246, miR-28-5p, and miR-765, showed distinct expression patterns with EV size, NSD, and PA. In vitro, endothelial cell (EC) barrier integrity directly correlated with miR-28-5p (r = 0.73, p = 0.007) and miR-765 (r=-0.58, p = 0.049). EC migration correlated negatively with miR-28-5p (r=-0.67, p = 0.02). Findings highlight smaller EV size associated with high NSD and low PA, suggesting miR-28-5p may be a biomarker or mediator for CVD pathogenesis. PA interventions may mitigate adverse SDoH effects and establish EV miRNA cargo as biomarkers and/or intervention mediators.

Indexed as

Cardiovascular DiseasesExerciseExtracellular VesiclesNeighborhood CharacteristicsAgedCohort StudiesFemaleHumansMicroRNAsMiddle AgedSocioeconomic Disparities in HealthMicroRNAsCardiovascular diseaseEndotheliumExtracellular vesiclesmiRNAPhysical activitySocial Determinants of Health

Identifiers

PMID42049829
PMCPMC13315576

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.