Evidence map›Paper›PMID 42049768›Full record

ArticleNPJ Parkinson's disease2026

The pattern of fMRI activation with STN DBS reveals symptom-specific networks.

Brendan Santyr, Aaron Loh, Jürgen Germann, Alexandre Boutet, Afis Ajala, Jianwei Qiu, Ghadh Albuainain, Mohamad Abbass, Radhika Madhavan, Gavin Elias and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Brendan SantyrDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Aaron LohDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Jürgen GermannDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Alexandre BoutetDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Afis AjalaGE HealthCare Technology & Innovation Center, Niskayuna, New York, NY, USA.
Jianwei QiuGE HealthCare Technology & Innovation Center, Niskayuna, New York, NY, USA.
Ghadh AlbuainainDepartment of Neurology, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Mohamad AbbassDepartment of Clinical Neurological Sciences, Western University, London, Toronto, ON, Canada.
Radhika MadhavanGE HealthCare Technology & Innovation Center, Niskayuna, New York, NY, USA.
Gavin EliasDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Artur VetkasDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Clement ChowDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Can SaricaDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Renato MunhozKrembil Brain Institute, Toronto, ON, Canada.
George M IbrahimDivision of Neurosurgery, Hospital for Sick Children, Toronto, ON, Canada.
Suneil KaliaDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Alfonso FasanoKrembil Brain Institute, Toronto, ON, Canada.
Andres M LozanoDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada. andres.lozano@uhn.ca.

Funding

Michael J Fox Foundation MJFF-008877National Institute of Neurological Disorders and Stroke of the National Institutes of Health 1R01NS133433-01
6 · The paper itself

Abstract

The network changes elicited by deep brain stimulation (DBS) in Parkinson's disease (PD) remain incompletely understood. We used functional MRI (fMRI) during active stimulation of the subthalamic nucleus (STN) to identify brain networks associated with clinical improvement. Forty PD patients (61 y ±8, 40% female) underwent 3-Tesla fMRI during active stimulation. Stimulation-induced changes in brain activity were correlated with outcomes (tremor, rigidity, bradykinesia, and axial instability). Symptom-specific fMRI response maps revealed distributed networks associated with long-term motor improvement, but ROI-based models showed poor out-of-sample performance and limited spatial stability. In contrast, somatomotor network modulation demonstrated symptom-specific coupling preferentially in rigidity improvement (ΔR² = 0.24, p

Identifiers

PMID42049768
PMCPMC13328640

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.