Evidence map›Paper›PMID 42049740›Full record

ArticleNature communications2026

Uromodulin p.His36Tyr promotes macrophage pyroptosis via App-Cd74 signaling to drive renal inflammation in ADTKD.

Qian-Qian Wu, Si-Qi Peng, Yi-Lin Zhang, Yan Yang, Wen Shi, Xian-Li Wen, Zhi-Ying Liu, Xu-Jie Zhou, Ming-Zhu Zheng, Li-Dan Hu and 10 more

Abstract read
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In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Qian-Qian Wu *Department of Nephrology, Zhongda Hospital, Southeast University, Nanjing, China.ORCID http://orcid.org/0000-0003-0430-2455
Si-Qi Peng *Department of Nephrology, Zhongda Hospital, Southeast University, Nanjing, China.
Yi-Lin Zhang *Department of Nephrology, Zhongda Hospital, Southeast University, Nanjing, China.
Yan YangDepartment of Nephrology, Zhongda Hospital, Southeast University, Nanjing, China.
Wen ShiDepartment of Nephrology, Zhongda Hospital, Southeast University, Nanjing, China.
Xian-Li WenDepartment of Pediatrics, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zhi-Ying LiuRenal Division, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China.
Xu-Jie ZhouRenal Division, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China.
Ming-Zhu ZhengDepartment of Pathogenic Biology and Immunology, School of Medicine, Southeast University, Nanjing, China.
Li-Dan HuZhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Xiao-Min LiDepartment of Nephrology, Zhongda Hospital, Southeast University, Nanjing, China.
Jing-Yuan CaoThe Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Taizhou, China.
Xin-Lu WangDepartment of Nephrology, Zhongda Hospital, Southeast University, Nanjing, China.
Jun-Lan YangDepartment of Nephrology, Zhongda Hospital, Southeast University, Nanjing, China.
Jin-Xuan WeiDepartment of Nephrology, Zhongda Hospital, Southeast University, Nanjing, China.
Jun-Yuan ShenDepartment of Nephrology, Zhongda Hospital, Southeast University, Nanjing, China.
Xiao-Xu WangDepartment of Nephrology, Zhongda Hospital, Southeast University, Nanjing, China.
Bi-Cheng LiuDepartment of Nephrology, Zhongda Hospital, Southeast University, Nanjing, China. liubc64@163.com.ORCID http://orcid.org/0000-0002-4584-1853
Xiao-Liang ZhangDepartment of Nephrology, Zhongda Hospital, Southeast University, Nanjing, China. tonyxlz@163.com.
Bin WangDepartment of Nephrology, Zhongda Hospital, Southeast University, Nanjing, China. wangbinhewei@126.com.ORCID http://orcid.org/0000-0003-1606-5004

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autosomal dominant tubulointerstitial kidney disease -UMOD is characterized by progressive renal interstitial inflammation and fibrosis. However, its underlying mechanisms remain unclear. Here, we identify a large ADTKD pedigree harboring a novel UMOD p.H36Y mutation. Using CRISPR/Cas9 technology, we generated a Umod

Indexed as

Amyloid beta-Protein PrecursorAntigens, Differentiation, B-LymphocyteMacrophagesPolycystic Kidney, Autosomal DominantPyroptosisUromodulinAnimalsDisease Models, AnimalFemaleHistocompatibility Antigens Class IIHumansInflammationKidneyMaleMiceMice, Inbred C57BLAmyloid beta-Protein PrecursorAntigens, Differentiation, B-LymphocyteHistocompatibility Antigens Class IIinvariant chainNF-kappa BUromodulin

Identifiers

PMID42049740
PMCPMC13334015

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.