Small heat shock and J-domain proteins direct defense against areca palm velarivirus 1 by degrading coat protein via autophagy.

Ruibai Zhao, Jie Lu, Zengyu Xing, Jinling Zhai, Hongxing Wang, Xianmei Cao, Xi Huang

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Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Ruibai Zhao *National Key Laboratory for Tropical Crop Breeding, School of Breeding and Multiplication, Sanya Institute of Breeding and Multiplication, Hainan University, Sanya, China.

Jie Lu *National Key Laboratory for Tropical Crop Breeding, School of Breeding and Multiplication, Sanya Institute of Breeding and Multiplication, Hainan University, Sanya, China.ORCID http://orcid.org/0009-0004-9320-210X

Zengyu XingNational Key Laboratory for Tropical Crop Breeding, School of Breeding and Multiplication, Sanya Institute of Breeding and Multiplication, Hainan University, Sanya, China.

Jinling ZhaiNational Key Laboratory for Tropical Crop Breeding, School of Breeding and Multiplication, Sanya Institute of Breeding and Multiplication, Hainan University, Sanya, China.

Hongxing WangNational Key Laboratory for Tropical Crop Breeding, School of Breeding and Multiplication, Sanya Institute of Breeding and Multiplication, Hainan University, Sanya, China.

Xianmei CaoNational Key Laboratory for Tropical Crop Breeding, School of Breeding and Multiplication, Sanya Institute of Breeding and Multiplication, Hainan University, Sanya, China. 184419@hainanu.edu.cn.ORCID http://orcid.org/0009-0007-6729-0072

Xi HuangNational Key Laboratory for Tropical Crop Breeding, School of Breeding and Multiplication, Sanya Institute of Breeding and Multiplication, Hainan University, Sanya, China. xihuang@hainanu.edu.cn.ORCID http://orcid.org/0000-0002-3605-2692

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Both autophagy and heat shock proteins (HSPs) play dual roles in viral infections, yet their coordination in antiviral defense remains unclear. Here, we show that a cytosolic small heat shock protein (AcsHSP) and a type II J-domain protein (AcDNAJB13) from areca palm interact with the coat protein (CP) of areca palm velarivirus 1 (APV1) independently of HSP70 chaperones. Their closest Nicotiana benthamiana homologs also bind CP. Both APV1 infection and CP expression induces the transcription of sHSP and DNAJB13, which in turn inhibits CP accumulation. Silencing of these genes enhances APV1 infection and CP accumulation, while overexpression of AcsHSP reduces viral accumulation. Mechanistically, CP is degraded via autophagy. Both AcsHSP and AcDNAJB13 interact with the autophagosome marker ATG8f1. However, AcsHSP strengthens CP-ATG8f1 binding, whereas AcDNAJB13 weakens it. These findings reveal distinct yet complementary mechanisms by which sHSP and DNAJB13 coordinate with autophagy to restrict viral infection.

Indexed as

AutophagyCapsid ProteinsHeat-Shock Proteins, SmallPlant ProteinsAutophagy-Related Protein 8 FamilyHSP40 Heat-Shock ProteinsNicotianaPicornaviralesPlant DiseasesProtein BindingProteolysisAutophagy-Related Protein 8 FamilyCapsid ProteinsHeat-Shock Proteins, SmallHSP40 Heat-Shock ProteinsPlant Proteins

Identifiers

PMID42049738

DOI10.1038/s41467-026-72498-2

PMCPMC13328657

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LicenceCC BY-NC-ND

Read underepoch 390

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.