Evidence map›Paper›PMID 42049709›Full record

ArticleMicrosystems & nanoengineering2026

Parallelized droplet microfluidic mechanoporation enables robust and clogging-resistant intracellular gene delivery.

Qingluan Liu, Aram J Chung

Abstract read
In one paragraph

Article in Microsystems & nanoengineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Qingluan LiuDepartment of Bioengineering, Korea University, 02841, Seoul, Republic of Korea.
Aram J ChungDepartment of Bioengineering, Korea University, 02841, Seoul, Republic of Korea. ac467@korea.ac.kr.ORCID http://orcid.org/0000-0003-4984-0222

Funding

National Research Foundation of Korea (NRF) 2021R1A2C2006224, RS-2023-00242443, RS-2023-00218543National Research Foundation of Korea (NRF) RS-2023-00242443, RS-2023-00218543
6 · The paper itself

Abstract

Microfluidic platforms have emerged as powerful tools for efficient intracellular delivery of exogenous cargo. While droplet microfluidics coupled with cell mechanoporation shows significant potential, its broader adoption is often hindered by channel clogging and limited scalability. To address these challenges, we developed a parallelized droplet-based cell mechanoporation platform with integrated bypass channels. This architecture stabilizes internal pressure and mitigates clogging-induced failure, ensuring robust and continuous operation. The platform achieves delivery efficiencies exceeding 98% and cell viabilities above 80% at a throughput of 2 × 10

Identifiers

PMID42049709
PMCPMC13125231

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.