Evidence map›Paper›PMID 42049446›Full record

ArticleIn vivo (Athens, Greece)

Association of TIMP2 Gene Variants With Development of Diabetic Retinopathy.

Chin-Te Huang, Hsiang-Wen Chien, Kai Wang, Shih-Chi Su, Chin-Han Ting, Shun-Fa Yang, Miao-Yu Liao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chin-Te HuangSchool of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C.
Hsiang-Wen ChienDepartment of Ophthalmology, Cathay General Hospital, Taipei, Taiwan, R.O.C.
Kai WangDepartment of Ophthalmology, Cathay General Hospital, Taipei, Taiwan, R.O.C.
Shih-Chi SuWhole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan, R.O.C.
Chin-Han TingInternational Department, Mingdao High School, Taichung, Taiwan, R.O.C.
Shun-Fa YangInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C.; ysf@csmu.edu.tw.
Miao-Yu LiaoDepartment of Family Medicine, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan, R.O.C. liaomiaoyu@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimDiabetic retinopathy (DR) is a common comorbidity of diabetes involving the formation of abnormal vascular structures in the retina. Tissue inhibitor of metalloproteinases 2 (TIMP2), initially identified as a key mediator of extracellular matrix turnover, is pivotal for inflammatory processes and tissue homeostasis. The current study examined the influence of MATERIALS AND

methodsWe investigated the association of

resultsOur results showed that rs16971783 of

conclusionAllele-specific expression of

Indexed as

Diabetic RetinopathyGenetic Association StudiesGenetic Predisposition to DiseasePolymorphism, Single NucleotideTissue Inhibitor of Metalloproteinase-2AgedAllelesFemaleGene FrequencyGenotypeHumansMaleMiddle AgedTIMP2 protein, humanTissue Inhibitor of Metalloproteinase-2diabetic retinopathygene polymorphismTissue inhibitor of metalloproteinases 2

Identifiers

PMID42049446
PMCPMC13133749

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.