Observational studyIn vivo (Athens, Greece)
Observational Study on the Effectiveness of L-Arginine Plus Vitamin C in the Management of Cancer-related Fatigue.
Observational study in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimCancer-related fatigue is one of the most distressing symptoms reported by patients with neoplastic disease. L-Arginine has a positive effect on physical performance in healthy individuals, on fatigue in diseases other than cancer, and on immune response in patients with cancer. PATIENTS AND
methodsForty-four patients with cancer undergoing medical treatment were treated orally with 1.66 g L-arginine and 500 mg of vitamin C
resultsDaily oral supplementation with L-arginine and vitamin C ameliorated cancer-related fatigue in a statistically significant manner. Health-related quality of life remained mostly unchanged despite patients having advanced cancer and being administered medical treatments including chemotherapy, immunotherapy and biological agents. No effect on appetite preservation was observed, except in a small percentage of patients.
conclusionOur exploratory study suggests a positive effect of oral supplementation with L-arginine plus vitamin C on cancer-related fatigue without significant worsening of quality of life. Due to the heterogeneity of the patient sample, further studies are needed including more clinically homogenous groups of patients.
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