Evidence map›Paper›PMID 42049441›Full record

ArticleIn vivo (Athens, Greece)

Live

Masayo Abe, Kohei Kamijyo, Shintaro Oda, Hiroshi Sakagami, Joichiro Hayashi, Megumi Inomata

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Masayo AbeDivision of Microbiology and Immunology, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry, Sakado, Japan.
Kohei KamijyoDivision of Periodontology, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry, Sakado, Japan.
Shintaro OdaDivision of Microbiology and Immunology, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry, Sakado, Japan.
Hiroshi SakagamiResearch Institute of Odontology (M-RIO), Meikai University School of Dentistry, Sakado, Japan.
Joichiro HayashiDivision of Periodontology, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry, Sakado, Japan.
Megumi InomataDivision of Microbiology and Immunology, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry, Sakado, Japan; inomata@dent.meikai.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimHuman periodontal ligament fibroblasts (PDLFs) can acquire osteoblast-like characteristics within periodontal lesions and contribute to osteoclastogenesis through the expression of receptor activator of nuclear factor (NF) κB ligand (RANKL). However, the microbial and cellular conditions required for RANKL induction remain unclear. This study compared the microbial responsiveness of undifferentiated and osteoblast-like PDLFs to clarify the mechanisms regulating RANKL expression. MATERIALS AND

methodsPDLFs were cultured in standard or osteogenic medium and stimulated with TLR2/TLR4 ligands, a Dectin-1 ligand, or infected with live or heat-killed

resultsUndifferentiated PDLFs failed to upregulate RANKL in response to TLR2/TLR4 ligands, a Dectin-1 ligand, or stimulation with live or heat-killed

conclusionRANKL induction in PDLFs requires osteoblast-like differentiation and multifactorial stimulation provided by live microbes, including synergistic interactions between bacteria and fungi. These findings offer new insights into the mechanisms driving periodontal bone destruction.

Indexed as

Candida albicansFibroblastsOsteoblastsPeriodontal LigamentPorphyromonas gingivalisRANK LigandCell DifferentiationCells, CulturedCell SurvivalGene Expression RegulationHumansOsteogenesisOsteoprotegerinToll-Like Receptor 2Toll-Like Receptor 4OsteoprotegerinRANK LigandTNFSF11 protein, humanToll-Like Receptor 2Toll-Like Receptor 4Candida albicansHuman periodontal ligament fibroblastsPorphyromonas gingivalisreceptor activator of NF-κB ligand

Identifiers

PMID42049441
PMCPMC13137397

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.