ArticleIn vivo (Athens, Greece)
Time-course Investigation of Bone and Disc Degeneration in a Rat Model of Pyogenic Spondylodiscitis.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
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Abstract
BACKGROUND/
aimPyogenic spondylodiscitis causes rapid endplate destruction followed by bone remodeling; however, the time-course of bone loss and recovery remains incompletely defined. This study aimed to characterize longitudinal changes in vertebral bone and intervertebral disc pathology in a rat tail pyogenic spondylodiscitis model. MATERIALS AND
methodsMale Sprague-Dawley rats (n=16) were allocated to 2-, 4-, or 6-week observation groups.
resultsThe bone destruction rate was significantly higher in the Discitis segment than in the Control segment at all time points, indicating persistent endplate damage. The disc height ratio decreased at 2 weeks but did not differ from controls at 4-6 weeks. Cancellous HU and trabecular parameters showed a biphasic pattern: decreased bone mass at 2 weeks, followed by recovery/reconstruction at 4-6 weeks. Histomorphometry demonstrated increased osteoclast activity (Oc.S/BS, Oc.N/BS) and osteoblast surface (Ob.S/BS) in the acute phase, with osteoclast indices decreasing over time, whereas osteoblast surface remained relatively elevated.
conclusionThis model demonstrated a biphasic bone metabolic response characterized by increased osteoclast-mediated bone resorption followed by bone formation and trabecular remodeling. Moreover, this model may serve as an experimental platform to investigate the optimal timing and strategies of therapeutic interventions.
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