ArticleIn vivo (Athens, Greece)
Obesity and Pro-Inflammatory Cytokines: Gene Expression Patterns Within Cervical Cancer Progression.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
BACKGROUND/
aimCervical cancer (CC) remains a significant global health concern, characterized by high incidence rates. Concurrently, the obesity epidemic continues to expand, affecting millions worldwide. Dysregulation of pro- and anti-inflammatory cytokines can promote chronic inflammation, which contributes to the pathogenesis of various diseases, including cancer. This study aimed to evaluate the gene expression levels of MATERIALS AND
methodsCervical samples were classified according to cervical diagnosis and body mass index (BMI). Gene expression levels of
resultsEighty-one women from the Colposcopy Clinic of Health Jurisdiction II in Ciudad Juarez were evaluated and classified into four groups: no intraepithelial lesion (NIL) (n=18), low-grade squamous intraepithelial lesion (LSIL) (n=22), high-grade squamous intraepithelial lesion (HSIL) (n=24), and CC (n=17). These groups were also classified based on BMI. The overexpression of TNF-α (
conclusionObesity is a risk factor for the development of CC by promoting a proinflammatory environment combined with a VPH infection.
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