Evidence map›Paper›PMID 42049430›Full record

ArticleIn vivo (Athens, Greece)

NLRP3 and RANK-RANKL-OPG Pathway-related Gene Expression Levels in Children With Autism Spectrum Disorder.

Bülent Kara, Merve Savaş, Tolgahan Özer, Şahika Gülen Şişmanlar, Remziye Akarsu, Sinem Yavuz Öztürk, Şeyma Nur Akpinar, Adnan Deniz, Ayfer Sakarya Güneş, Fulya Dursun and 3 more

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Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Bülent KaraDivision of Child Neurology, Department of Pediatrics, Kocaeli University Faculty of Medicine, Kocaeli, Turkey; bkuskudar@gmail.com.
Merve SavaşDepartment of Language and Speech Therapy, Faculty of Health Sciences, Atlas University, Istanbul, Turkey.
Tolgahan ÖzerDepartment of Medical Genetics, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
Şahika Gülen ŞişmanlarDepartment of Child and Adolescent Psychiatry, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
Remziye AkarsuDepartment of Occupational Therapy, Faculty of Health Sciences, Biruni University, Istanbul, Turkey.
Sinem Yavuz ÖztürkDepartment of Child and Adolescent Psychiatry, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
Şeyma Nur AkpinarDepartment of Child and Adolescent Psychiatry, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
Adnan DenizDivision of Child Neurology, Department of Pediatrics, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
Ayfer Sakarya GüneşDivision of Child Neurology, Department of Pediatrics, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
Fulya DursunDepartment of Medical Genetics, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
Deniz Sünnetçi AkkoyunluDepartment of Medical Genetics, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
Naci ÇineDepartment of Medical Genetics, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
Erdem TüzünDepartment of Neurological Sciences, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimAltered glial function, and increased proinflammatory cytokines are associated with behavioral and cognitive problems seen in autism spectrum disorder (ASD). In this study, we aimed to investigate the neuroinflammatory process in ASD and the relationship between neuroinflammatory markers and the severity of autism symptoms. MATERIALS AND

methodsWe evaluated the gene expression levels of NLRP-3 and RANK-RANKL-OPG inflammasome pathways in 50 children with ASD (AC), 34 typically developing siblings (HSAC), and 16 healthy controls (HC) and the correlation between gene expression levels and severity of neuro-psychiatric dysfunctions in ASD. All children were aged 3-18 years. The severity of autism core symptoms and neurologic dysfunction was determined by the Childhood Autism Rating Scale (CARS), Turkish Communication Development Inventory (TCDI), Dunn's Sensory Profile, Adolescents/Adults Sensory Profile and Clinical Observation of Neuromotor Performance, and the scores were correlated with gene expression levels.

resultsUp-regulation was observed in all genes (

conclusionThis is the first study showing that the RANK-RANKL-OPG pathway is active in ASD cases. Our results emphasize the harmful influence of the RANK-RANKL-OPG and NLRP3 inflammasome complexes on neurologic development.

Indexed as

Autism Spectrum DisorderNLR Family, Pyrin Domain-Containing 3 ProteinOsteoprotegerinRANK LigandReceptor Activator of Nuclear Factor-kappa BSignal TransductionAdolescentChildChild, PreschoolFemaleGene Expression RegulationHumansInflammasomesMaleInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanOsteoprotegerinRANK LigandReceptor Activator of Nuclear Factor-kappa BTNFRSF11B protein, humanTNFSF11 protein, humanAutism spectrum disorderinflammasomeneuroinflammationNLRP3RANK-RANKL-OPG pathway

Identifiers

PMID42049430
PMCPMC13133836

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.