ArticleIn vivo (Athens, Greece)
Alternate-day Capecitabine Plus Trastuzumab for Frail HER2-positive Gastric Cancer: A Pilot Case Series.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimPatients who are frail with advanced gastric cancer often have a limited tolerance to standard daily chemotherapy, resulting in restricted treatment options. Although alternate-day administration of S-1 has been reported as a low-burden strategy, to the best of our knowledge, the feasibility of alternate-day capecitabine administration has not been evaluated clinically. This study assessed the feasibility and tolerability of alternate-day capecitabine administration in patients with advanced gastric cancer who were frail or pre-frail. PATIENTS AND
methodsSix patients who were frail or pre-frail with histologically confirmed advanced gastric cancer were retrospectively analyzed. Frailty was assessed using the Vulnerable Elders Survey-13 (VES-13), with scores of 2 and ≥3 defined as pre-frail and frail, respectively. Capecitabine was administered at a standard daily dose of 2,000 mg/m
resultsThe median age was 77 years, and the VES-13 scores ranged from 2 to 7. The overall response rate was 33%, and the disease control rate was 83%. The median overall survival was 11 months, with two patients surviving for over 24 months. The cumulative dose of capecitabine delivered was approximately 57% of that obtained with standard daily administration. Hematologic toxicities included one case each of grade 3 febrile neutropenia and grade 4 anemia, whereas nonhematologic toxicities were mostly grades 1-2. No treatment-related deaths occurred.
conclusionAlternate-day capecitabine without a reduction in the daily dose is a feasible treatment modification option, including in combination with trastuzumab, for managing patients with HER2-positive gastric cancer who are frail or pre-frail.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.