ArticleIn vivo (Athens, Greece)
Effects of Short-term High-dose Vitamin D Supplementation on Mineral Homeostasis in Healthy Young Adults.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
aimHigh-dose vitamin D supplementation is increasingly used to achieve extraskeletal effects, but its safety regarding mineral metabolism remains under discussion. This study assessed the effects of vitamin D on serum calcium, magnesium, and parathyroid hormone (PTH) concentrations in young healthy individuals. MATERIALS AND
methodsSixty-five healthy volunteers received cholecalciferol drops in doses ranging from 1,000 to 8,000 IU/day across two winter seasons. Serum concentrations of 25-hydroxyvitamin D [25(OH)D], calcium, magnesium, and PTH were measured at defined intervals.
resultsSupplementation resulted in a dose-dependent increase in serum 25(OH)D, reaching a maximum of 208.5 nmol/l. Despite the high intake, all measured parameters remained within physiological ranges. A significant inverse association between 25(OH)D and PTH levels confirmed physiological suppression of PTH at higher vitamin D concentrations, though all values stayed within reference limits.
conclusionThe absence of clinically relevant disturbances in calcium, magnesium, or PTH levels supports the safety of high-dose vitamin D supplementation when appropriately monitored in young healthy adults, even at the upper limits of therapeutic dosing. These findings highlight the need for further research to delineate the long-term effects of high-dose vitamin D supplementation on mineral metabolism across diverse patient populations.
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