ArticleIn vivo (Athens, Greece)
Symptom Burden in Adenomyosis: A Comparative Analysis With Peritoneal and Deep Infiltrating Endometriosis.
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Abstract
BACKGROUND/
aimAdenomyosis frequently coexists with endometriosis and shares overlapping symptoms; however, the symptom burden of isolated adenomyosis remains insufficiently defined. The aim of this study was to compare the severity and distribution of symptoms in patients with isolated adenomyosis PATIENTS AND
methodsThis retrospective study analyzed standardized preoperative symptom questionnaires from women who underwent surgery for suspected endometriosis at a tertiary referral center in 2021. Patients were classified intraoperatively using the #ENZIAN system and allocated to three groups: isolated adenomyosis (AM), peritoneal/ovarian endometriosis with or without adenomyosis, and DIE with or without additional disease.
resultsA total of 231 patients were included (isolated AM: n=42; peritoneal/ovarian endometriosis: n=120; DIE: n=69). Dysmenorrhea was highly prevalent across all groups (95-100%). Chronic pelvic pain and dyspareunia, including severe dyspareunia, were reported more frequently in patients with isolated AM and peritoneal/ovarian disease than in those with DIE (
conclusionAM is associated with a symptom burden comparable to that of peritoneal and DIE. These findings underscore adenomyosis as a clinically significant cause of pelvic pain and highlight the need for early recognition and appropriate management.
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