Evidence map›Paper›PMID 42049394›Full record

ArticleRMD open2026

Impact of postpartum on patients with rheumatoid arthritis and spondyloarthritis: an ancillary analysis of the GR2 prospective cohort.

Marie Hornez, Anna Molto, Maxime Leroy, Béatrice Banneville, Rakiba Belkhir, Elodie Chauvet, Marion Couderc, Emmanuelle Dernis, Valérie Devauchelle-Pensec, Aline Frazier and 11 more

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in RMD open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02450396 (Prospective Observational Study About Pregnancy and Medically Assisted Conception in Rare Diseases), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02450396 withdrawnnot on this map

Prospective Observational Study About Pregnancy and Medically Assisted Conception in Rare Diseases

TypeobservationalSponsorAssistance Publique - Hôpitaux de ParisRan2015 to 2025Enrolled0ConditionsRheumatoid Arthritis, Spondyloarthritis, Psoriatic Arthritis, Systemic Lupus Erythematosus
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Marie HornezService de Rhumatologie, Université de Lille, CHU Lille, Lille, France.ORCID 0009-0002-2635-4264
Anna MoltoCentre for Research in Epidemiology and Statistics, Université Paris Cité; Université Sorbonne Paris Nord; INSERM; INRAE, Paris, France.ORCID 0000-0003-2246-1986
Maxime LeroyDepartment of Biostatistics, CHU Lille, Lille, France.
Béatrice BannevilleService de Rhumatologie, Sorbonne Université and Pitié Salpêtrière Hospital, Paris, France.
Rakiba BelkhirService de Rhumatologie, Université Paris-Saclay, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Le Kremlin-Bicetre, France.
Elodie ChauvetService de Médecine Interne, CHU Montpellier, Montpellier, France.
Marion CoudercService de Rhumatologie, CHU Gabriel Montpied, Clermont-Ferrand, France.ORCID 0000-0002-2001-1132
Emmanuelle DernisService de Rhumatologie, CHU Caen, Caen, France.
Valérie Devauchelle-PensecService de Rhumatologie, UMR1227, Lymphocytes B et Autoimmunité, Université de Bretagne occidentale, Inserm, CHU Brest, LabEx IGO, Brest, France.
Aline FrazierService de Rhumatologie, Université Paris Cité, AP-HP, Hôpital Lariboisière, Paris, France.
Laure GossecService de Rhumatologie, Sorbonne Université and Pitié Salpêtrière Hospital, Paris, France.ORCID 0000-0002-4528-310X
Elisabeth GervaisService de Rhumatologie, CHU Poitiers, Poitiers, France.
Hubert MarotteService de Rhumatologie, Université Jean Monnet Saint-Étienne, CHU Saint-Etienne, Mines Saint-Etienne, INSERM, SAINBIOSE U1059, Saint-Étienne, France.ORCID 0000-0003-1177-9497
Christophe RichezService de Rhumatologie, National Reference Center for Systemic Autoimmune Rare Diseases, Bordeaux University Hospital, Hôpital Pellegrin, Bordeaux, France.
Jérémie SellamService de Rhumatologie, Hôpital Saint-Antoine; Assistance Publique-Hôpitaux de Paris (AP-HP); Sorbonne Université, Paris, France.
Raphaele SerorService de Rhumatologie, Université Paris-Saclay, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Le Kremlin-Bicetre, France.ORCID 0000-0002-5523-1856
Véronique Le GuernService de Médecine Interne, Centre de Référence Maladies Autoimmunes et Systémiques Rares Île de France, APHP Hôpital Cochin, Paris, France.
Gaëlle Guettrot-ImbertService de Médecine Interne, Centre de Référence Maladies Autoimmunes et Systémiques Rares Île de France, APHP Hôpital Cochin, Paris, France.
Nathalie Costedoat-ChalumeauService de Médecine Interne, Centre de Référence Maladies Autoimmunes et Systémiques Rares Île de France, APHP Hôpital Cochin, Paris, France.ORCID 0000-0002-1555-9021
René-Marc FlipoService de Rhumatologie, Université de Lille, CHU Lille, FHU PRECISE, Lille, France.
Jean-Guillaume LetarouillyService de Rhumatologie, Université de Lille, CHU Lille, FHU PRECISE, U1286 - INFINITE - Institute for Translational Research in Inflammation, Lille, France Jeanguillaume.letarouilly@chu-lille.fr.ORCID 0000-0003-2793-6303

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo describe disease activity and treatments received during the postpartum period, breastfeeding rates and their possible impact on rheumatoid arthritis (RA) and spondyloarthritis (SpA) activity.

methodThis ancillary study from the French multicentre prospective cohort (GR2-NCT02450396) included pregnant women with RA and SpA with at least one postpartum visit from October 2014 to October 2022. Disease activity, flares, treatments and breastfeeding rates were described. Factors associated with the occurrence of a flare were evaluated by survival analysis. Disease activity was compared according to breastfeeding duration (never, <6 months and ≥6 months).

resultsNinety-four RA and 124 SpA patients were studied. In RA patients, the proportion of patients presenting with at least one flare was significantly higher during the first 6 months postpartum compared with pregnancy (62.0% vs 43.5%; p=0.02). For SpA patients, there was no difference in disease activity at 6 months postpartum compared with pregnancy (40.7% vs 40.7%; p=0.999). Disease activity in postpartum was similar between the different breastfeeding status in both diseases. 13/91 (14.3%) RA patients and 29/123 (23.6%) SpA patients continued a biologic Disease-Modifying Antirheumatic Drug (bDMARD) during the whole pregnancy and the postpartum. 78/91 RA and 94/123 SpA patients delivered without any DMARDs, and among them, 43/78 (55.1%) and 56/94 (59.6%) (re)started a bDMARD postpartum.

conclusionRA patients were more likely to flare during early postpartum, while SpA patients remained stable. bDMARD continuation during pregnancy was more frequent in SpA patients, and half of the patients restarted bDMARD during postpartum.

Indexed as

Arthritis, RheumatoidPostpartum PeriodSpondylarthritisAdultBreast FeedingFemaleFranceHumansPregnancyProspective StudiesSeverity of Illness IndexArthritis, RheumatoidAxial SpondyloarthritisBiological Therapy

Identifiers

PMID42049394
PMCPMC13141108

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