SynthesisObesity reviews : an official journal of the International Association for the Study of Obesity2026
Effects of Weight Loss Interventions on Gut Microbiota-Derived Metabolites Linked to Cardiometabolic Health: A Systematic Review and Meta-Analysis.
Synthesis in Obesity reviews : an official journal of the International Association for the Study of Obesity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- New insights into the gut-heart axis: microbial metabolite biomarkers, multi-omics, and engineered bacterial delivery systems.Frontiers in microbiology · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundGut microbiota-derived metabolites are emerging as potential mediators between obesity and cardiometabolic conditions. While weight loss interventions modify microbiota composition, their effects on systemic microbial metabolites remain unclear.
objectiveTo evaluate the effect of weight loss interventions on circulating levels of key gut-derived metabolites in individuals with overweight or obesity, through a systematic review and meta-analysis.
methodsSearches were performed in MEDLINE, EMBASE, and The Cochrane Library up to July 17, 2024. We included intervention studies in individuals with overweight/obesity undergoing weight loss strategies, with measurement of serum lipopolysaccharides (LPSs), trimethylamine N-oxide (TMAO), secondary bile acids, short-chain fatty acids (SCFAs), or indole derivatives. Meta-analysis used the standardized mean difference (SMD) with a random-effects model, stratified by intervention type (non-surgical or surgical).
resultsSixty-seven studies were included. Non-surgical interventions were associated with reduced TMAO (n = 8 studies; SMD: -0.56; 95% CI -0.90 to -0.22; I
conclusionWeight loss strategies have distinct effects on gut microbiota-derived metabolites, underscoring the complexity of microbiota-host interactions and the potential for personalized approaches to obesity treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.