Evidence map›Paper›PMID 42049303›Full record

ArticleBMJ open2026

Study protocol of the e-Intervention Enhancing Mental Health in Adolescents (IMPROVA) project: a randomised controlled trial to promote adolescents' mental health and well-being in four European countries.

Rodrigo Antunes Lima, Harald Baumeister, Rüdiger Pryss, Ann-Marie Küchler, Robin Kraft, Nils Berghoff, Luzia Nagel, Manfred Reichert, Abdul Rahman Idrees, Michael Stach and 22 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06556576 (e-Intervention Enhancing Mental Health in Adolescents), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06556576 nanot yet recruitingnot on this map

e-Intervention Enhancing Mental Health in Adolescents (IMPROVA)

TypeinterventionalSponsorFundació Sant Joan de DéuRan2024 to 2025Enrolled6,000ConditionsWell-Being, Psychological, Depressive Symptoms, Social IsolationArmsIMPROVA Platform
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Rodrigo Antunes LimaImpact and Prevention of Mental Disorders Research Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Spain rodrigoantunes.lima@sjd.es.ORCID http://orcid.org/0000-0002-7778-2616
Harald BaumeisterClinical Psychology and Psychotherapy, University of Ulm, Ulm, Germany.
Rüdiger PryssInstitute of Medical Data Science, University Hospital Wurzburg, Würzburg, Germany.
Ann-Marie KüchlerImpact and Prevention of Mental Disorders Research Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Spain.
Robin KraftInstitute of Medical Data Science, University Hospital Wurzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0003-0657-3232
Nils BerghoffClinical Psychology and Psychotherapy, University of Ulm, Ulm, Germany.
Luzia NagelClinical Psychology and Psychotherapy, University of Ulm, Ulm, Germany.
Manfred ReichertInstitute of Databases and Information Systems, Ulm University, Ulm, BW, Germany.
Abdul Rahman IdreesInstitute of Medical Data Science, University Hospital Wurzburg, Würzburg, Germany.
Michael StachInstitute of Medical Data Science, University Hospital Wurzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0001-9422-5523
Maria MelchiorINSERM, Pierre Louis Institute of Epidemiology and Public Health, IPLESP, Social Epidemiology, Mental Health and Addictions, ESSMA, Sorbonne Université, Paris, France.ORCID http://orcid.org/0000-0002-2377-619X
Camille Davisse-PaturetINSERM, Pierre Louis Institute of Epidemiology and Public Health, IPLESP, Social Epidemiology, Mental Health and Addictions, ESSMA, Sorbonne Université, Paris, France.
Emma FalkinerINSERM, Pierre Louis Institute of Epidemiology and Public Health, IPLESP, Social Epidemiology, Mental Health and Addictions, ESSMA, Sorbonne Université, Paris, France.
Judith van der WaerdenPierre Louis Institute of Epidemiology and Public Health, IPLESP, Social Epidemiology, Mental Health and Addictions, ESSMA, Sorbonne Université, INSERM, Paris, France.
Adriana BabanDepartment of Psychology, Babes-Bolyai University, Romania, Cluj-Napoca, Romania.
Diana TautDepartment of Psychology, Babes-Bolyai University, Romania, Cluj-Napoca, Romania.
Ingrid DanilaDepartment of Psychology, Babes-Bolyai University, Romania, Cluj-Napoca, Romania.
Mariona Perez-AntonImpact and Prevention of Mental Disorders Research Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Spain.
Daniele PorricelliImpact and Prevention of Mental Disorders Research Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Spain.
Julia SanguesaImpact and Prevention of Mental Disorders Research Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Spain.
Maria Victoria MonetaImpact and Prevention of Mental Disorders Research Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Spain.ORCID http://orcid.org/0000-0002-1224-3742
Rocío García-CarriónDepartment of Education, University of Deusto, Bilbao, Spain.ORCID http://orcid.org/0000-0002-5520-5105
Catrin FinkenauerDepartment of Interdisciplinary Social Science, Utrecht University, Utrecht, Netherlands.
Gonneke Wjm StevensDepartment of Interdisciplinary Social Science, Utrecht University, Utrecht, Netherlands.
Lydia KrabbendamDepartment of Clinical, Neuro-and Developmental Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Felix BolinskiDepartment of Public Mental Health, Trimbos Instituut, Netherlands Institute of Mental Health and Addiction, Utrecht, Netherlands.
Petra MaresovaBetthera s.r.o, Hradec Králové, Czech Republic.
Per NilsenDepartment of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Nadine KarlssonDepartment of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Natalia MorenoAjuntament de Sant Boi de Llobregat, Sant Boi de Llobregat, Spain.
Anaïs Le CorvecCliclab Transformative Agent SL, Barcelona, Spain.
Josep Maria HaroImpact and Prevention of Mental Disorders Research Group, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis trial aims to evaluate the impact of the IMPROVA intervention programme in improving mental health, quality of life, and well-being in adolescents enrolled in secondary schools in four European countries. METHODS AND ANALYSIS: The IMPROVA intervention will be evaluated using a two-arm parallel group pragmatic cluster randomised controlled trial with an intervention and a wait-list control group. Secondary schools in France, Germany, Romania, and Spain were recruited. Originally, we estimated to enrol a total of 6000 students within 64 schools; that is, 16 schools per country. The IMPROVA programme is a multi-level intervention that provides tailored content for adolescents, families, and school staff. This content creates a unified and supportive framework that promotes mental health and social-emotional development among adolescents. A series of implementation strategies was planned to support the uptake of the programme into the education setting and among participants. Study outcomes were assessed at baseline, mid-term (during the intervention), postintervention (primary end point), and will be assessed at postintervention (secondary end-point; 6 months after postintervention). Overall mental health (Strengths and Difficulties Questionnaire) is the primary outcome. Secondary outcomes include: health-related quality of life, depression, anxiety, social isolation, and self-esteem. The trial will be evaluated regarding its effectiveness, cost-effectiveness, implementation, and social return on investment analysis. ETHICS AND DISSEMINATION: This study has received the approval of human research ethics committees in France (Comité de Protection des Personnes Ile-de-France VIII", No. 2024-A00201-46), Germany (Ulm University Ethics Committee, No. 186-24), Romania (The Research Ethics Subcommittee of the Babeș-Bolyai University of Cluj-Napoca, No. 14.146/23.09.2024), and Spain (CEIm Fundació Sant Joan de Déu, No. PIC-61-24). Results will be disseminated through peer-reviewed open-access publications and presentations at national and international conferences. Non-technical summaries will be shared with public health authorities, participants, and stakeholder organisations. All findings will be reported in aggregate form, ensuring no individual participant can be identified. TRIAL REGISTRATION NUMBER: NCT06556576.

Indexed as

Health PromotionMental HealthQuality of LifeAdolescentCost-Benefit AnalysisEuropeFemaleHumansPsychological Well-BeingRandomized Controlled Trials as TopicSpainAdolescentsCommunity child healtheHealthMENTAL HEALTHPsychosocial Intervention

Identifiers

PMID42049303
PMCPMC13141090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.