Evidence map›Paper›PMID 42048792›Full record

ArticlePoultry science2026

Ligilactobacillus salivarius 8-2 attenuates intestinal mucosal injury in chicks via the mitochondrial fision-glycometabolism reprogramming axis.

Yuping Hua, Minyao Zou, Lingzhi Zhang, Leixiao Chen, Xi Rao, Guozhen Wei, Jiaxin Wei, Mingping Wei, Yihang Wei, Jian Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuping HuaMOA Key Laboratory of Animal Virology, College of Animal Sciences, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou 310058, PR China; Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, PR China; Zhejiang Provincial Engineering Research Center of Animal Biological Products, Zhejiang University Center for Veterinary Sciences, Hangzhou 310058, PR China.
Minyao ZouMOA Key Laboratory of Animal Virology, College of Animal Sciences, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou 310058, PR China; Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, PR China; Zhejiang Provincial Engineering Research Center of Animal Biological Products, Zhejiang University Center for Veterinary Sciences, Hangzhou 310058, PR China.
Lingzhi ZhangMOA Key Laboratory of Animal Virology, College of Animal Sciences, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou 310058, PR China; Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, PR China; Zhejiang Provincial Engineering Research Center of Animal Biological Products, Zhejiang University Center for Veterinary Sciences, Hangzhou 310058, PR China.
Leixiao ChenMOA Key Laboratory of Animal Virology, College of Animal Sciences, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou 310058, PR China; Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, PR China; Zhejiang Provincial Engineering Research Center of Animal Biological Products, Zhejiang University Center for Veterinary Sciences, Hangzhou 310058, PR China.
Xi RaoQingliu Animal Husbandry, Veterinary and Aquatic Products Center, Sanming 365300, PR China.
Guozhen WeiQingliu Animal Husbandry, Veterinary and Aquatic Products Center, Sanming 365300, PR China.
Jiaxin WeiFujian Vocational College of Agriculture, Fuzhou 350000, PR China.
Mingping WeiFujian Xin Fengqiang agriculture Co., LTD, Sanming 365300, PR China.
Yihang WeiFujian Xin Fengqiang agriculture Co., LTD, Sanming 365300, PR China.
Jian LiMOA Key Laboratory of Animal Virology, College of Animal Sciences, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou 310058, PR China; Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, PR China; Zhejiang Provincial Engineering Research Center of Animal Biological Products, Zhejiang University Center for Veterinary Sciences, Hangzhou 310058, PR China. Electronic address: lijiannp@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intestinal mucosa is crucial for nutrient absorption and barrier function. In this study, a newly identified strain of Ligilactobacillus salivarius (L. sa. 8-2) exhibited a mucosal protective effect in chick intestinal injury models. However, the underlying mechanisms need to be clarified. In vivo, chicks were pre-fed with L. sa. 8-2 supernatant or its precipitate and then challenged with lipopolysaccharide (LPS) or Salmonella Typhimurium (STm). The results showed that L. sa. 8-2 and its supernatant significantly reduced intestinal epithelial apoptosis, increased goblet cell density and Muc2 mRNA abundance, and upregulated Claudin1 protein levels. Specifically, compared with the LPS-challenged group, L. sa. 8-2 supernatant accelerated epithelial renewal, as shown by elevated protein levels of proliferating cell nuclear antigen (PCNA) and increased mRNA abundance of cell cycle regulators Ccnd1 and Cdk2. Moreover, the L. sa. 8-2 supernatant markedly increased protein levels of both the active intestinal stem cell (aISC) marker LGR5 and the reserve ISC (rISC) marker HOPX in the intestinal crypt. In vitro, the enteroids were pre-treated with L. sa. 8-2 supernatant and then challenged with LPS. It was shown that the L. sa. 8-2 supernatant elevated the protein levels of LGR5 and HOPX compared with the injured group. Moreover, co-staining of LGR5 and HOPX revealed that more HOPX

Indexed as

ChickensIntestinal MucosaMitochondriaPoultry DiseasesProbioticsAnimalsIntestinal Barrier FunctionLipopolysaccharidesMaleSalmonella typhimuriumLipopolysaccharidesEnergy metabolismIntestinal stem cellMucosal barrierMucosal repairProbiotics

Identifiers

PMID42048792
PMCPMC13138049

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.