Evidence map›Paper›PMID 42048523›Full record

ArticleJournal of medical Internet research2026

Building EVA (

Diego Humberto Vasquez, Neil Rupani, Carmen Contreras, Lenka Kolevic, Molly Forrest Franke, Jerome Timothy Galea

Abstract read
In one paragraph

Article in Journal of medical Internet research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Diego Humberto Vasquez *Socios En Salud Sucursal Peru, Lima, Peru.ORCID http://orcid.org/0009-0007-0668-2750
Neil Rupani *Morsani College of Medicine, University of South Florida, Tampa, FL, United States.ORCID http://orcid.org/0000-0001-7798-3808
Carmen ContrerasSocios En Salud Sucursal Peru, Lima, Peru.ORCID http://orcid.org/0000-0001-6184-3819
Lenka KolevicInstituto Nacional de Salud del Niño, Lima, Peru.ORCID http://orcid.org/0000-0003-0433-3622
Molly Forrest FrankeDepartment of Global Health and Social Medicine, Harvard Medical School, Harvard University, Boston, MA, United States.ORCID http://orcid.org/0000-0002-4890-5728
Jerome Timothy GaleaSchool of Social Work, College of Behavorial and Community Sciences, University of South Florida, 13301 Bruce B Downs Blvd, MHC 1400, Tampa, FL, 33612-3807, United States, 1 813 974 2310.ORCID http://orcid.org/0000-0001-8732-6959

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unlabelled: Adolescents living with HIV face higher rates of mental health morbidity compared to other age groups, particularly depressive symptoms, while access to specialized services remains limited in many low- and middle-income countries. Chatbots offer a promising, low-cost approach to delivering structured mental health support in resource-constrained settings; however, practical guidance on how to develop such tools with end-user involvement remains scarce. This tutorial provides a step-by-step guide to the human-centered design and development of a mental health chatbot for adolescents living with HIV, illustrated through the creation of EVA (Educación, Vinculación, y Autoayuda), a chatbot cocreated with adolescents living with HIV in Peru. Guided by human-centered design principles, the tutorial covers three key steps: (1) understanding user needs through qualitative research, (2) iterative chatbot development with a Youth Advisory Board across five structured sessions, and (3) external review and testing before launch. Throughout the process, adolescents contributed to defining the chatbot's tone, visual identity, navigation structure, and content priorities. The chatbot was built using a low-cost messaging platform and incorporated multimedia components, including brief animated videos, to enhance engagement. Throughout development, iterative testing with the Youth Advisory Board and external health care professionals informed refinements in usability, content clarity, emotional tone, and accessibility. This tutorial synthesizes key methodological decisions, lessons learned, and challenges encountered, providing practical guidance for researchers and practitioners seeking to develop similar adolescent-centered digital mental health tools in low- and middle-income countries. Key takeaways include the importance of early and sustained adolescent involvement, the value of iterative prototyping, and the feasibility of building functional chatbots with limited resources to help address the health service gap experienced by adolescents living with HIV.

Indexed as

HIV InfectionsMental HealthAdolescentDigital HealthDigital MediaHumansMental Health TeletherapyadolescentchatbotdepressionHIVmental healthmHealthmobile health

Identifiers

PMID42048523
PMCPMC13123754

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.