Evidence map›Paper›PMID 42048457›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Suppression rather than activation of the integrated stress response (GCN2-ATF4) pathway extends lifespan in the fly.

Miriam S Götz, Dan J Hayman, Gracie Adams, Fumiaki Obata, Mirre J P Simons

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Miriam S GötzSchool of Biosciences, University of Sheffield, Sheffield S10 2TN, United Kingdom.ORCID 0009-0002-7187-2626
Dan J HaymanSchool of Biosciences, University of Sheffield, Sheffield S10 2TN, United Kingdom.ORCID 0000-0001-9125-1945
Gracie AdamsSchool of Biosciences, University of Sheffield, Sheffield S10 2TN, United Kingdom.
Fumiaki ObataRIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo 650-0047, Japan.ORCID 0000-0002-8641-5818
Mirre J P SimonsSchool of Biosciences, University of Sheffield, Sheffield S10 2TN, United Kingdom.ORCID 0000-0001-7406-7708

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
NIH HHS P40 OD018537Royal Society (The Royal Society) ICA\R2\242197Vivensa ECRF24\13Wellcome 216405/Z/19/ZWellcome Trust
6 · The paper itself

Abstract

Stress response pathways are emerging as conserved modulators of lifespan. The prevailing hypothesis is that activation of stress-responsive pathways, including the amino acid deprivation arm of the integrated stress response (ISR; the GCN2-ATF4 pathway), is prolongevity. Activation of

Indexed as

Activating Transcription Factor 4Drosophila melanogasterDrosophila ProteinsIntegrated Stress ResponseLongevityAnimalsProtein KinasesSignal TransductionStress, PhysiologicalTranscription FactorsActivating Transcription Factor 4crc protein, DrosophilaDrosophila ProteinsGCN2 protein, DrosophilaProtein KinasesTranscription Factorsagingborrelidinintegrated stress responsetranscriptomicstRNA

Identifiers

PMID42048457
PMCPMC13142962

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.