Evidence map›Paper›PMID 42048445›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

LRBA organizes distinct vesicular trafficking systems in distal nephron segments for water and sodium conservation.

Kanako Nagaoka, Fumiaki Ando, Tamami Fujiki, Hassan Abolhassani, Yu Hara, Hideki Yanagawa, Soichiro Suzuki, Yuriko Sakamaki, Daisuke Oikawa, Hiroaki Kikuchi and 15 more

Abstract read
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In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Kanako NagaokaDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8519, Japan.
Fumiaki AndoDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8519, Japan.ORCID 0000-0002-8401-1705
Tamami FujikiDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8519, Japan.ORCID 0000-0002-6697-5930
Hassan AbolhassaniResearch Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran 1419733151, Iran.ORCID 0000-0002-4838-0407
Yu HaraDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8519, Japan.
Hideki YanagawaDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8519, Japan.
Soichiro SuzukiDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8519, Japan.
Yuriko SakamakiOchanomizu Research Facility, Bioscience Center, Institute of Science Tokyo, Tokyo 113-8510, Japan.
Daisuke OikawaDepartment of Medical Biochemistry, Graduate School of Medicine, Osaka Metropolitan University, Osaka 545-8585, Japan.
Hiroaki KikuchiDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8519, Japan.
Shintaro MandaiDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8519, Japan.ORCID 0000-0001-6709-306X
Yutaro MoriDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8519, Japan.
Takayasu MoriDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8519, Japan.ORCID 0000-0002-9308-7787
Koichiro SusaDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8519, Japan.
Eisei SoharaDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8519, Japan.ORCID 0000-0003-1668-8308
Akihiro HoshinoDepartment of Child Health and Development, Institute of Science Tokyo, Tokyo 113-8519, Japan.
Tsuyoshi ItoDepartment of Pediatrics, Toyohashi Municipal Hospital, Aichi 441-8570, Japan.
Yuki ArakawaDepartment of Hematology/Oncology, Saitama Children's Medical Center, Saitama 330-8777, Japan.
Yoji SasaharaDepartment of Pediatrics, Tohoku University Graduate School of Medicine, Miyagi 980-8574, Japan.ORCID 0000-0003-0030-1535
Shinsuke YasudaDepartment of Rheumatology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8519, Japan.ORCID 0000-0001-6171-2077
Yoichiro AbeDepartment of Pharmacology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Masato YasuiDepartment of Pharmacology, Keio University School of Medicine, Tokyo 160-8582, Japan.ORCID 0000-0002-5481-1779
Fuminori TokunagaDepartment of Medical Biochemistry, Graduate School of Medicine, Osaka Metropolitan University, Osaka 545-8585, Japan.
Hirokazu KaneganeDepartment of Child Health and Development, Institute of Science Tokyo, Tokyo 113-8519, Japan.
Shinichi UchidaDepartment of Nephrology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8519, Japan.

Funding

Japan Agency for Medical Research and Development (AMED) JP22ek0109608 and JP25ym0126803Japan Intractable Diseases Research Foundation (JIDRF) 2024A01Japan Research Foundation for Clinical Pharmacology N/AMEXT | Japan Society for the Promotion of Science (JSPS) 21H02933 25K02567MEXT | Japan Society for the Promotion of Science (JSPS) 22H03085 and 25K02666MEXT | Japan Society for the Promotion of Science (JSPS) 24K19126MEXT | Japan Society for the Promotion of Science (JSPS) 25K19484Ono Medical Research Foundation N/ATakeda Science Foundation (TSF) N/AThe Mother and Child Health Foundation N/AYoung Innovative Medical Scentist Unit N/AYoung Innovative Medical Scientist Unit N/A
6 · The paper itself

Abstract

Lipopolysaccharide-responsive and beige-like anchor protein (LRBA) deficiency is a rare genetic disorder characterized by immune dysregulation. The immune checkpoint molecule cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) fails to perform proper membrane trafficking in the absence of LRBA. In addition to immune cells, LRBA localizes to intracellular vesicles in various epithelial cells; however, its physiological roles have not been accurately deciphered. It was observed in this study that LRBA facilitates water and sodium transport by promoting vesicular trafficking of aquaporin-2 (AQP2) and AQP4 in renal collecting duct cells and that of sterile 20/SPS1-related proline/alanine-rich kinase (SPAK) in distal convoluted tubule cells. Consequently,

Indexed as

Adaptor Proteins, Signal TransducingNephronsSodiumWaterAnimalsAquaporin 2Deamino Arginine VasopressinFemaleHumansKidney Tubules, CollectingMiceMice, KnockoutPolyuriaProtein Serine-Threonine KinasesAdaptor Proteins, Signal TransducingAqp2 protein, mouseAquaporin 2Deamino Arginine VasopressinProtein Serine-Threonine KinasesSodiumStk39 protein, mouseWaterAQPshypotensionLRBApolyuriaSPAK

Identifiers

PMID42048445
PMCPMC13142998

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.