Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Joseph D ClossonStructural Biology Initiative, City University of New York Advanced Science Research Center, New York, NY 10031.
Xingjian XuStructural Biology Initiative, City University of New York Advanced Science Research Center, New York, NY 10031.ORCID 0000-0002-9609-4755
Meiling ZhangStructural Biology Initiative, City University of New York Advanced Science Research Center, New York, NY 10031.ORCID 0000-0002-0670-6018
Tarsisius T TiyaniStructural Biology Initiative, City University of New York Advanced Science Research Center, New York, NY 10031.
Leandro Pimentel MarcelinoStructural Biology Initiative, City University of New York Advanced Science Research Center, New York, NY 10031.ORCID 0000-0001-6067-0725
Eta A IsiorhoStructural Biology Initiative, City University of New York Advanced Science Research Center, New York, NY 10031.ORCID 0000-0002-6242-9297
Jason S NagatiDepartment of Medicine, Columbia University Irving Medical Center, New York, NY 10032.ORCID 0000-0002-4507-6581
Joseph A GarciaDepartment of Medicine, Columbia University Irving Medical Center, New York, NY 10032.ORCID 0000-0002-5621-7538
Kevin H GardnerStructural Biology Initiative, City University of New York Advanced Science Research Center, New York, NY 10031.ORCID 0000-0002-8671-2556
Funding
Training and Career Development CoreU54CA132378 · NCI · CITY COLLEGE OF NEW YORK · PI Bao Q Vuong · 2008 to 2026
$28.9M
Training and Career Development and Education CoreU54CA137788 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Daniel Alan Heller · 2008 to 2026
$28.1M
BLRD VA I01 BX000446G. Harold and Leila Y. Mathers Foundation (Mathers Foundation) MF-2112-02288NCI NIH HHS U54 CA132378NCI NIH HHS U54 CA137788U.S. Department of Veterans Affairs (VA) I01BX000446
6 · The paper itself
Abstract
Hypoxia inducible factors (HIFs) are heterodimeric transcription factors that coordinate cellular responses to low oxygen levels by binding a short hypoxia response element (HRE) DNA sequence near O
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Context-dependent variability of HIF heterodimers influences interactions with macromolecular and small molecule partners. · full record | OpenQuestion