ArticlePloS one2026
Comparative study of ocular and generalized myasthenia gravis in a South Korean cohort.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Acetylcholine Receptor Antibody Positivity, RNST Abnormality, and Thymoma Predict Generalization in Ocular Myasthenia Gravis: A South Korean Cohort Study.Antibodies (Basel, Switzerland) · 2026Article
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3 authors.
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Abstract
purposeTo compare ocular myasthenia gravis (OMG) and generalized myasthenia gravis (GMG) in a South Korean cohort through an integrated analysis of clinical characteristics, diagnostic findings, and treatment patterns.
methodsWe conducted a retrospective study of 138 patients with myasthenia gravis (98 with OMG and 40 with GMG). Demographic characteristics, ophthalmic symptoms, serologic results, repetitive nerve stimulation test (RNST) findings, thymic pathology, autoimmune comorbidities, and treatment patterns were evaluated.
resultsGMG patients had a younger age at symptom onset and a higher proportion of females compared with OMG patients. Combined horizontal and vertical diplopia was more frequent in OMG. AChR antibody positivity was significantly higher in GMG than in OMG (92.5% vs. 36.3%), as were abnormal RNST findings (90.0% vs. 23.5%). A modest but statistically significant positive correlation was observed between AChR-Ab titer and the highest CMAP decrement in the overall cohort (r = 0.381, p = 0.011); however, this association was not significant when analyzed separately in OMG and GMG patients. Thymic abnormalities, particularly thymoma, were more common in GMG. Nonsteroidal immunosuppressant use-especially tacrolimus and azathioprine-was significantly more frequent in GMG, whereas corticosteroid use did not differ significantly between subtypes. Among OMG patients, systemic immunotherapy was more frequently administered to those presenting with both ptosis and diplopia than to those with isolated ptosis.
conclusionsIn this South Korean cohort, OMG and GMG exhibited distinct demographic, serologic, electrophysiologic, and therapeutic profiles. Recognition of these subtype-specific differences may facilitate accurate diagnosis, individualized treatment selection, and improved clinical management.
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