Evidence map›Paper›PMID 42048271›Full record

ArticleFolia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)2026

Respiratory-Swallow Training and Variable Practice in Parkinson's Disease: A Clinical Trial Pilot Study.

James A Curtis, James C Borders, Brianna Kiefer, Roy N Alcalay, Richard Magill, Lori Quinn, Lisa Edmonds, Sonja Molfenter, Michelle S Troche

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In one paragraph

Article in Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

James A CurtisAerodigestive Innovations Research Lab (AIR), Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medical College of Cornell University, New York, New York, USA, yrj9003@med.cornell.edu.
James C BordersDepartment of Speech, Language, and Hearing Sciences, Boston University, Boston, Massachusetts, USA.
Brianna KieferDepartment of Physical Medicine and Rehabilitation, University of California Davis Medical Center, Sacramento, California, USA.
Roy N AlcalayDivision of Movement Disorders, Department of Neurology, The Neurological Institute, Columbia University Irving Medical Center, New York, New York, USA.
Richard MagillMotor Learning and Control Program, Department of Biobehavioral Sciences, Teachers College of Columbia University, New York, New York, USA.
Lori QuinnNeurorehabilitation Research Lab (NRL), Movement Sciences and Kinesiology Program, Department of Biobehavioral Sciences, Teachers College of Columbia University, New York, New York, USA.
Lisa EdmondsAphasia Rehabilitation & Bilingualism Lab, Department of Biobehavioral Sciences, Teachers College of Columbia University, New York, New York, USA.
Sonja MolfenterNYU Swallowing Research Lab, Communicative Sciences and Disorders Program, NYU Steinhardt School of Culture, Education, and Human Development, New York University, New York, New York, USA.
Michelle S TrocheLaboratory for the Study of Upper Airway Dysfunction, Communication Sciences and Disorders Program, Department of Biobehavioral Sciences, Teachers College, Columbia University, New York, New York, USA.

Funding

Effectiveness of Expiratory Muscle Strength Training for Improving Communication in ALSF31DC019281 · NIDCD · PURDUE UNIVERSITY · PI KIEFER, BRIANNA ROSE · 2020 to 2022
$92k
NIDCD NIH HHS F31 DC019281
6 · The paper itself

Abstract

introductionDysphagia in people with Parkinson's disease (PwPD) is closely linked to impairments in respiratory-swallow coordination. Respiratory-swallow training (RST) is a promising, mechanism-based intervention for dysphagia, but, to date, only a single-subject study has examined RST in PwPD. As an early-stage next step in refining RST for PwPD, this clinical trial pilot study aimed to: (1) explore the preliminary associations between exhale-swallow-exhale (EX-EX) RST and swallowing safety, swallowing efficiency, and respiratory phase patterning; and (2) explore differences in practice structure (constant vs. variable practice) on RST-related motor learning outcomes.

methodsPwPD completed pre-RST assessments, four once-weekly sessions of RST targeting only the EX-EX pattern, and post-RST assessments. Participants were randomized to constant practice or variable practice training conditions. Outcomes were measured using nasal airflow, respiratory inductive plethysmography, submental surface electromyography, and flexible endoscopic evaluation of swallowing. Multilevel statistical models were used to evaluate changes in EX-EX usage, pharyngeal residue, penetration, and aspiration.

resultsTwelve PwPD completed all study phases, yielding an analysis of 1,565 swallows. In this pilot sample, EX-EX usage was higher post-RST compared to pre-RST (p < 0.05), with EX-EX usage observed to be higher at 1-month follow-up in the variable practice group compared to the constant practice group (p < 0.05). Additionally, pharyngeal residue, laryngeal vestibule residue, vocal fold residue, and Penetration-Aspiration Scale scores were lower post-RST compared to pre-RST (p < 0.05).

conclusionThis clinical trial pilot study provides preliminary evidence that RST may be associated with increased EX-EX usage, swallowing safety, and swallowing efficiency in PwPD. Preliminary evidence also suggests that variable practice may enhance retention and generalization of EX-EX usage, warranting further evaluation. Findings from this study will be used to inform refinement of RST for PwPD and the design of future confirmatory randomized clinical trials.

Indexed as

AspirationDysphagiaFlexible endoscopic evaluation of swallowingParkinson’s diseaseRespiratory-swallow coordination

Identifiers

PMID42048271
PMCPMC13313620

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.