Evidence map›Paper›PMID 42048039›Full record

ArticleMolecular and cellular biochemistry2026

Co-translational profiling in the cardiac endothelium in response to LPS-induced inflammation in female mice in vivo: a proof-of-concept approach.

Chad M Warren, Bhairavi Swaminathan, Paulina Langa, Stephanie R Villa, Walter C Thompson, Magdalena Chrzanowska, Jan K Kitajewski, R John Solaro, Beata M Wolska, Paul H Goldspink

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chad M WarrenDepartment of Physiology and Biophysics, University of Illinois, Chicago, IL, USA.
Bhairavi SwaminathanDepartment of Physiology and Biophysics, University of Illinois, Chicago, IL, USA.
Paulina LangaDepartment of Physiology and Biophysics, University of Illinois, Chicago, IL, USA.
Stephanie R VillaDepartment of Physiology and Biophysics, University of Illinois, Chicago, IL, USA.
Walter C ThompsonDepartment of Physiology and Biophysics, University of Illinois, Chicago, IL, USA.
Magdalena ChrzanowskaVersiti Blood Research Institute, Milwaukee, WI, USA.
Jan K KitajewskiDepartment of Physiology and Biophysics, University of Illinois, Chicago, IL, USA.
R John SolaroDepartment of Physiology and Biophysics, University of Illinois, Chicago, IL, USA.
Beata M WolskaDepartment of Physiology and Biophysics, University of Illinois, Chicago, IL, USA.
Paul H GoldspinkDepartment of Physiology and Biophysics, University of Illinois, Chicago, IL, USA. pgolds@uic.edu.

Funding

Signaling To and From the Vascular/Endothelial Compartment and Progression of HCM Linked to Sarcomere MutationsR01HL158634 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GOLDSPINK, PAUL H, SOLARO, R JOHN · 2022 to 2025
$3.1M
Endothelial Rap1 in the control of heart functionR01HL157893 · NHLBI · VERSITI WISCONSIN, INC. · PI CHRZANOWSKA, MAGDALENA, GOLDSPINK, PAUL H · 2022 to 2025
$2.9M
Co-translational Regulation in the Vasculature of Organ Systems with AgingR21AG080316 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GOLDSPINK, PAUL H · 2023 to 2024
$440k
NHLBI NIH HHS R01 HL157893NHLBI NIH HHS R01 HL158634NIA NIH HHS R21 AG080316NIH HHS NHLBI RO1 HL112626NIH HHS NHLBI RO1 HL157893NIH HHS NHLBI RO1 HL158634
6 · The paper itself

Abstract

Producing functional proteins involves multiple steps during mRNA translation on the ribosomes. However, co-translational regulatory mechanisms remain poorly characterized in intact mammalian systems. As a proof-of-concept, we developed a multi-omics approach to investigate endothelial-specific, co-translational regulation by modifying the translating ribosome affinity purification (TRAP) in vivo. We simultaneously co-immunoprecipitated (IP) polysome-associated mRNAs and proteins from the hearts of hemagglutinin-tagged ribosomal protein L22 mice (RiboTag) crossed with inducible endothelial-specific Cdh5CreERT2 mice (RiboTag

Indexed as

Endothelium, VascularInflammationLipopolysaccharidesMyocardiumProtein BiosynthesisAnimalsAntigens, CDCadherin 5CadherinsFemaleMiceMultiomicsPlatelet Endothelial Cell Adhesion Molecule-1ProteomicsRNA, MessengerAntigens, CDCadherin 5CadherinsLipopolysaccharidesPecam1 protein, mousePlatelet Endothelial Cell Adhesion Molecule-1RNA, MessengerEndotheliumHeartLipopolysaccharideRibosomeTranslatome

Identifiers

PMID42048039
PMCPMC13279726

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.