ArticleInternational urology and nephrology2026
Tumor-derived extracellular vesicles exert promotional effects on metastasis in renal cell carcinoma through the delivery of microRNA-671-5p.
Article in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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Who cites it
1 citing paper in PubMed.
- Advances in Exosome Research in Renal Cell Carcinoma: Mechanisms, Biomarkers, and Therapeutic Applications.International journal of nanomedicine · 2026Review
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Authors and funding
4 authors.
Funding
Abstract
purposeTumor-derived extracellular vesicles (EVs) can deliver microRNAs (miRNAs) to promote tumor development. Herein, this study explored whether tumor-derived EVs carrying miR-671-5p facilitated renal cell carcinoma (RCC) cell growth.
methodsmiR-671-5p expression in RCC cells and the collected EVs was assessed. After gain- and loss-of-function assays and EV co-culture, cell viability, invasion and migration, and apoptosis were measured. RNA pull-down and dual-luciferase reporter assays were used to analyze the binding between miR-671-5p and inhibitor of growth 5 (ING5). The function of EVs in RCC metastasis in vivo was evaluated through tumor transplantation in nude mice.
resultsmiR-671-5p was up-regulated in RCC cells and EVs from ACHN cells. miR-671-5p down-regulation inhibited RCC cell proliferation, invasion, and migration but accelerated cell apoptosis. EVs derived from ACHN cells carried miR-671-5p into RCC cells. RCC cell invasion, migration, and proliferation were diminished but cell apoptosis was elevated after co-culture with EVs carrying inhibitors-miR-671-5p. Mechanistically, ING5 was a target of miR-671-5p. ING5 silencing abrogated the effects of EVs carrying inhibitors-miR-671-5p on RCC cells. EVs accelerated tumor growth, increased tumor volume, and elevated Ki-67-positive cells in mice, accompanied by increased miR-671-5p expression and decreased ING5 expression, whereas EVs carrying inhibitors-miR-671-5p contributed to opposite results.
conclusionTumor-derived EVs carrying miR-671-5p target ING5 to promote RCC cell growth.
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Registered trials
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