ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026
Disrupted emotion-memory interactions in behavioral variant frontotemporal dementia.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveAutobiographical memory specificity is markedly reduced in behavioral variant frontotemporal dementia (bvFTD). Because emotion is known to facilitate autobiographical memory retrieval in healthy adults, we investigated whether emotional cueing could enhance autobiographical specificity in bvFTD.
methodsPatients with bvFTD and age-matched healthy control participants were asked to retrieve autobiographical memories in response to positive, negative, and neutral cue words. Participants were also asked to rate the emotional valence of the memories they retrieved.
resultsAcross all cue conditions, patients with bvFTD demonstrated lower autobiographical specificity than control participants. However, emotional cues did not modulate autobiographical specificity in bvFTD, as memories elicited by positive, negative, and neutral cues were comparable in both specificity and emotional valence. In contrast, control participants showed a strong emotional cueing effect, with positive cues eliciting more specific and emotionally positive memories than neutral or negative cues. Emotional valence ratings further revealed a dissociation between groups, with control participants showing differentiated emotional responses across cue conditions, whereas patients with bvFTD exhibited a flattened emotional profile.
conclusionTogether, these findings indicate that emotional cues fail to enhance autobiographical specificity or emotional experience in bvFTD, highlighting a profound disruption in emotion–memory integration that may contribute to altered self-related processing in this condition.
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