Evidence map›Paper›PMID 42047709›Full record

ArticleJournal of the American Chemical Society2026

Probing Weak Halogen Bonding in Aqueous Solution.

Manuel A Herbst, Leyun Wu, Yannik T Woordes, Stefan Peintner, Jian Xin, Frank M Boeckler, Zhijian Xu, Weiliang Zhu, Armando Navarro-Vázquez, Mate Erdelyi

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Manuel A HerbstDepartment of Chemistry for Life Sciences, Uppsala University, Uppsala SE-751 23, Sweden.ORCID 0000-0002-1534-6413
Leyun WuDepartment of Chemistry for Life Sciences, Uppsala University, Uppsala SE-751 23, Sweden.
Yannik T WoordesDepartment of Chemistry for Life Sciences, Uppsala University, Uppsala SE-751 23, Sweden.ORCID 0009-0007-5550-6788
Stefan PeintnerDepartment of Chemistry for Life Sciences, Uppsala University, Uppsala SE-751 23, Sweden.
Jian XinDepartment of Pharmacy and Biochemistry, Eberhard Karls University Tübingen, Tübingen 72076, Germany.
Frank M BoecklerDepartment of Pharmacy and Biochemistry, Eberhard Karls University Tübingen, Tübingen 72076, Germany.ORCID 0000-0001-8738-6716
Zhijian XuState Key Laboratory of Drug Research; Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.ORCID 0000-0002-3063-8473
Weiliang ZhuState Key Laboratory of Drug Research; Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.ORCID 0000-0001-6699-5299
Armando Navarro-VázquezDepartamento de Química Fundamental, Centro de Ciências Exatas e da Natureza, Universidade Federal de Pernambuco, Recife, Pernambuco 50740-560, Brazil.ORCID 0000-0003-4364-516X
Mate ErdelyiDepartment of Chemistry for Life Sciences, Uppsala University, Uppsala SE-751 23, Sweden.ORCID 0000-0003-0359-5970

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Noncovalent interactions are as important for chemistry and biology as they are difficult to characterize. They determine the 3D structure of biopolymers, the binding mode and affinity of drug candidates, and the mechanisms and kinetics of enzymatic reactions and molecular recognition events, to name a few examples of processes that take place in aqueous solution. A single noncovalent force, with its inherent weakness, yields transient low-affinity complexes that are especially challenging to detect in dilute solutions, especially in polar and protic solvents that offer competing interactions, such as water. Using weak halogen bonding (<20 kJ mol

Identifiers

PMID42047709
PMCPMC13184976

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.